Hydroxychloroquine-based COVID-19 Treatment, A Systematic Review of Clinical Evidence and Expert Opinion from Physicians’ Surveys

Key Words: hydroxychloroquine, azithromycin, antiviral, evidence

Abstract

During the current COVID-19 epidemic, most of the evidence is collected by treating physicians, most of whom do not report their results in peer reviewed journals.  Hence, there appears to be an especially broad gap between field experience and academic coverage of hydroxychloroquine-based COVID-19 treatments. The objective of this study is to bring field evidence into the academic literature.

Four relevant, non-academic surveys of physicians, in the US and globally, have been identified and checked for quality, statistical significance, coverage, and conflicts of interest. To avoid uninformed and unduly influenced opinions, only surveys conducted from April 4 to April 19 have been considered. These surveys were answered by thousands of physicians, who treated tens of thousands of COVID-19 patients.

The results: 85% of doctors said that hydroxychloroquine is at least somewhat effective for COVID-19. Hydroxychloroquine was the most utilized treatment for COVID-19 patients.  35%-40% of the doctors using the drug called it very effective or extremely effective against COVID-19. 65% of doctors said they would prescribe hydroxychloroquine for COVID-19 to their family members.

The author declares no competing interest.

No funding was provided for this work.

All relevant ethical guidelines have been followed.

Introduction

The largest body of knowledge of COVID-19 treatments is collected by practicing physicians, outside of research settings, and not reported in peer reviewed publications. The objective of this systematic review is to capture some of this clinical experience and bring it into the academic literature. The scope is limited to hydroxychloroquine-based treatments, administered in the early (viral) stages of COVID-19.

The most effective and popular COVID-19 treatment regimen, combining hydroxychloroquine with azithromycin, was introduced by Institut Hospitalo-Universitaire (IHU) Méditerranée Infection, directed by Didier Raoult.  The HCQ based treatment was presented at a March 16, 2020 conference (Raoult, 2020), and published a few days later as (Gautret, et al., 2020). It became instantly popular among physicians on March 20-21.

Many doctors and hospitals used this treatment from March 20 to March 27.  The treatment’s effects were observed and discussed with colleagues, from March 27 to April 4. Thus, starting around April 4, doctors who used or observed the use of any HCQ-based treatment were able to provide eyewitness testimonies. Many other doctors were able to give their expert opinions, based on the experiences of their colleagues and their professional knowledge. On April 20, the NIH COVID-19 Panel published guidelines that were adverse to HCQ treatment (The National Institutes of Health COVID-19 Treatment Guidelines Panel , 2020). On April 24, the FDA issued a warning (The FDA, 2020) concerning the drug’s safety. These events might have prejudiced some doctors against HCQ. The time frame chosen for this systematic review, April 4 to April 19, is selected to ensure that physicians had sufficient experience with HCQ but had not yet been prejudiced by external events.

Explanation of Methods

A physician’s answers to questions regarding the treatment s/he has used can be considered direct evidence. Corresponding statistics computed from the responses of N physicians, treating on average M patients, should have equal power and higher resilience than results of a randomized clinical trial conducted on N*M patients, in the absence of a systematic bias.

A physician’s choice of a certain treatment over another, indicates that the chosen treatment is considered more effective. A physician’s decision to implement a certain treatment rather than no treatment proves that the treatment’s effectiveness/risk profile is considered high enough. This can be considered indirect evidence.

A physician’s opinion about a treatment which he or she did not directly use in practice, but learned about from other physicians, can be considered an expert opinion.

Well implemented surveys can capture much of this evidence and expert opinions.

Methods

Surveys or polls of physicians were sought, using multiple search engines (DuckDuckGo, Bing, Google, Yandex), searching for ‘physician survey hydroxychloroquine’, ‘doctors survey hydroxychloroquine’, and similar combinations of keywords; no quotes; not limited by dates. The search was repeated many times, excluding previously found items.

Surveys or polls from three companies were found. Each of the three survey companies were researched and confirmed as reputable. A list of all relevant surveys and polls, done by these three companies, in the selected time frame, was compiled. This yielded four surveys from three different companies: Sermo (two surveys), InCrowd, and Jackson Coker. Sermo’s surveys appeared to be most professional and informative. No strong competing interests, that may have any bearing on the surveys, were found in any of the three companies.

Drugs used for other effects, other than antiviral, have been excluded from this review for the following reasons. High dose steroids are used during a cytokine storm. Acetaminophen, Ibuprofen, and Herbal remedies are used as symptomatic treatment. Vitamin D is not considered an antiviral treatment or an essential part of one. Bronchodilators are bronchodilators.

Results

Although the surveys posed different questions to different audiences, the results were congruent. Because CQ is hardly used in practice, CQ and HCQ are both referred to as HCQ.

Table 1. Summary of results

 J CSermo W3Sermo W4InCrowd
Polling DateApril 4-7April 6-9April 13-15April 14-15
Publication DateApril 8April 15April 23April 21
LocationUSAGlobalGlobalUSA
# doctors127140165500203
Recommended HCQ65% (1)n/an/an/a
# COVID-19 treatersn/a13371376 (3)203
Used HCQ / HCQ+AZn/a50%53%n/a
% HCQ users rating VEE (4)n/a40%35%n/a
Reported HCQ effectiven/a85% (5)n/an/a
Would give to patients’ %n/an/an/a30% (2)
Remarks  HCQ shortages 
  • Would give HCQ to their family
  • Would prescribe HCQ / HCQ+AZ to this percentage of their COVID-19 patients, on average. 30% is quite a high number, because most COVID-19 patients probably need no treatment, especially the patients of the surveyed physicians, about a third of whom are pediatricians. The numbers for plasma and Remdesivir are 21% and 16%, respectively.
  • This number includes physicians who used HCQ in outpatient and hospital ex/ICU settings.
  • VEE = Very or Extremely Effective (4 or 5 on the scale 0 – 5)
  • 2 or higher on the scale 0 – 5

Notice that except for Jackson Coker, surveys’ results were published about a week after they had been conducted, so their results could not influence each other.

Sermo Week 3

(Sermo W3, 2020)

Survey Period: April 6-9

Published on April 15

Country: Global

N = 4016 – the total number of physicians surveyed, including those who have not treated COVID-19

Effectiveness:

The top treatments used or seen to be used by physicians and reported as very or extremely effective among COVID-19 treaters include:

Table 2. VEE Treatments

Hydroxychloroquine                          n=875 (40%)

Plasma from recovered patients      n=363 (46%)

Percentage of physicians to report that HCQ/CQ is at least partially effective (scoring 2 or higher on the scale 0 – 5) against COVID-19:

Table 3. Physicians rating HCQ/CQ at least partially effective

Global:         85%

US:                 81%

Italy:              94%

Spain:           91%

China:          88%

This data suggests that physicians in countries with more than average COVID-19 experience appreciate HCQ more than physicians in countries with less than average experience.

Usage

N = 1337 (the number of COVID-19 treaters out of the 4016 physicians surveyed)

SCREENING: COVID-19 treaters

Table 4. Medications physicians have used to treat COVID-19 patients

Drug%
Azithromycin or similar antibiotics58%
Hydroxychloroquine or Chloroquine50%
Anti-HIV drugs (e.g. Lopinavir plus Ritonavir)23%
Drugs used to treat flu (e.g., Oseltamivir)22%
None16%

Treatments used by less than 10% COVID-19 treaters are excluded here.

The survey did not include inquiries about drug combinations.  However, these numbers and well-known information from other sources suggest that in most cases when HCQ or CQ was prescribed, it was in combination with Azithromycin (AZ).

There were important differences in the perceived effectiveness of HCQ in the US as compared to the rest of the world. In the US, HCQ/CQ was used by 39% of COVID-19 treaters, compared to 75% and 83% of practitioners in Spain and Italy, respectively. Of note, Spain and Italy broke the rapid rise and started a rapid decrease in death rates around April 2-3  (Our World in Data, 2020).

Sermo Week 4

(Sermo W4, 2020)

Survey Period: April 13-15

Published on April 23

Country: Global

N = 1376 (after screening; 5,500 doctors were surveyed)

SCREENING: COVID-19 treaters

Effectiveness

N = 1376 (636 Non-Hospital physicians / 1045 Hospital physicians; except ICU only)

Q11. Effectiveness on patients outside hospital setting (Mild/Moderate): For patients you treat outside the hospital (mild/moderate in community setting), rate the efficacy of medications you have used to treat COVID-19.

NET: Very/Extremely Effective (Don’t Know Excluded)

Table 5. VEE Treatments

Non-HospitalHospital ex/ICU
n=636 (Q8)n=1,045 (Q9)
Hydroxychloroquine88 (38%)196 (31%)
Azithromycin79 (23%)126 (19%)
Vitamin C39 (26%)36 (19%)
Drugs to treat flu31 (24%)66 (26%)
Plasma23 (68%)63 (61%)
Zinc20 (25%)19 (20%)
Anti-HIV drugs19 (27%)71 (22%)
Remdesivir10 (27%)50 (34%)

Results ordered by the number of physicians who rated the drug Very/Extremely Effective in the more relevant, non-hospital group. (Results are listed only for drugs in Table 6 in the next section) Notice that percentages in parentheses exclude treaters who did not answer the question about each drug’s effectiveness. Effectiveness of HCQ was rated differently in different countries. In the US, it was rated below its rating in the rest of the world.

HCQ / HCQ+AZ is clearly in the league of its own, per number of physicians rating it as “Very or Extremely Effective”.

Usage

N = 1376 (636 / 1045 for Non-Hospital physicians / Hospital physicians, except ICU only)

SCREENING: COVID-19 treaters

Table 6. Share of COVID-19 Treating Physicians Who’ve Used Medication Within Setting 

Non-HospitalHospital ex/ICUComputed Average
n=636 (Q8)n=1,045 (Q9)
Azithromycin60%70%65%
Hydroxychloroquine40%66%53%
Drugs to treat flu22%25%23.5%
Anti-HIV drugs12%32%22%
Vitamin C28%21%24.5%
Zinc 17%11%14%
Remdesivir 6%16%11%
Plasma6%10%8%

Simple averages have been computed to reflect the higher probability that HCQ-based treatment was started early in non-hospital settings compared with hospital settings.

Given the low standalone effectiveness and broad use of AZ, it is likely that in most cases HCQ was used in combination with AZ. The relatively large percentage for physicians using and highly rating Zinc suggests that HCQ+AZ+Zn was used extensively.

Note 1

33% of treaters complained about HCQ shortages. For comparison, only 27% of the treaters complained about ventilator shortages. The number was 48% for Super Treaters (doctors who treated >20 COVID-19 patients) outside of hospital settings. It is reasonable to conclude that HCQ treatment results would have been even better if not for HCQ shortages, causing treatment delays.

Note 2

This survey captures the relevant results of treating about 25,000 – 30,000 COVID-19 patients (Q7).

InCrowd

(InCrowd, 2020)

Survey Period: April 14-15

Published on April 21

N = 203

Country: USA

Specialties: US Primary Care Physicians (61), Pediatricians (59), and Emergency Medicine or Critical Care Physicians (83)

SCREENING: Physicians who have or are currently treating 20 or more patients with flu like symptoms

Q11: For what percentage of your COVID-19 patient population would you prescribe each of the following treatments? If other, please specify.

The offered options are: Acetaminophen, Antibiotics (e.g. azithromycin, etc.), Bronchodilators, Hydroxychloroquine, Plasma (from recovered patients), Ibuprofen, Remdesivir, Antivirals, Chloroquine, Steroids (High Dose), Flu treatments (e.g. Tamiflu, Xofluza), Herbal remedies, Anti-HIV Drugs, Interferon-Beta, Other.

Table 7. Surveyed physicians would prescribe to this % of their COVID-19 patients

Drug%
Azithromycin etc.”  41%
Hydroxychloroquine or Chloroquine30%
Plasma21%
Remdesivir16%
Antivirals (non-specific)10%

Flu treatments (e.g. Tamiflu, Xofluza), Anti-HIV Drugs, Interferon-Beta, and Other scored 2%-7% each.

No answers were reported about the combination of drugs, but the numbers suggest that non-pediatric doctors would prescribe HCQ+AZ to ~40% of their COVID-19 patients. Many physicians using HCQ prescribe it only to those deemed at risk, so 30-40% is impressive.

Jackson Coker

(Jackson-Coker, 2020)

Survey Period: April 4-7

Published on April 8

N= 1,271

Country: USA, all 50 states

Reported margin of error is 3% with a 95% confidence level.

SCREENING: None. All physicians who elected to answer the survey, about 1% of the firm’s database of physicians. It was not established whether they treated or did not treat COVID-19 patients. It is likely that there was positive self-selection by doctors who treated COVID-19.

65% said they would prescribe drugs chloroquine or hydroxychloroquine to treat or prevent COVID-19 in a family member. 54% said they would prescribe it early, while another 11% said they would prescribe it if the disease becomes serious. 30% said they would prescribe chloroquine or hydroxychloroquine to a family member prior to the onset of symptoms if they had been exposed to the coronavirus. 11% said they would not use the drug.

73% of physicians practicing solo or with ownership stake in a practice, said they would prescribe HCQ/CQ to a family member. That means that more experienced physicians are more likely to prescribe HCQ. The share drops among critical care, emergency medicine, and hospitalists to 43%, 55%, 54%, respectively.

The lower usage of HCQ by critical care and emergency physicians can be explained by the fact that they are dealing with patients in a later stage of COVID-19, which might be characterized as a different illness, dominated by ADRS and multiple organs damage, rather than by viral infection.

Discussion

Only a small fraction of physicians use plasma, but they highly rate it.

Doctors’ wide-spread use and high recognition of HCQ+AZ treatment against COVID-19 is strong evidence, and, possibly, conclusive proof of the treatment’s safety and effectiveness.

Later Surveys

Sermo’s weekly COVID-19 surveys break the results down by regions, countries, and other useful categories. Sermo continued publishing surveys about doctors’ choices of COVID-19 treatments even after April 19. In May, they reported a decline in the use of CQ/HCQ and a rise in the use of Remdesivir.

InCrowd conducted a similar survey on May 29-31. It also reported a decline in the use of CQ/HCQ and a rise of Remdesivir, possibly for external reasons.

Jackson Coker has conducted no other related surveys.

Remarks

Some doctors started adding Zinc to the HCQ+AZ cocktail, as reported in (Risch, 2020). It is expected that additional experience in treating COVID-19, since the surveyed period, has increased the safety and effectiveness of multiple treatments, including HCQ-based ones.

Conclusions

85% of the globally surveyed physicians recognized HCQ as at least partially effective in treating COVID-19, according to Sermo W3. More than half of the surveyed US physicians would take the drug or give it to family members early or even before onset of symptoms, according to JC.

Aside from the rarely used plasma, HCQ / HCQ+AZ based treatments are preferred by physicians by wide margin over other drugs.  HCQ / HCQ+AZ based treatments are the most used, most recommended, and most highly rated by physicians treating COVID-19 at an early stage.

Personal Note

Except for this paragraph, this paper appears here exactly as it was submitted to medrxiv.org on June 30 (MEDRXIV/2020/143800). It was rejected today, on July 4: “We regret to inform you that your manuscript will not be posted. A small number of papers are deemed during screening to be more appropriate for dissemination after peer review at a journal rather than as preprints.

I felt this might happen when I saw medrxiv’s home page “Supported by Chan Zuckerberg Initiative“. Now, I submit it to an open peer review.

On a side note, speaking of New Paper Demonstrates Strong Efficacy of Hydroxychloroquine. Mortality rate cut in half!

there is an earlier peer-reviewed paper, confirming HCQ+AZ effectiveness:

Jean-Christophe Lagierab, Matthieu Million, Philippe Gautret, Raoult, Didier et al., Outcomes of 3,737 COVID-19 patients treated with hydroxychloroquine/azithromycin and other regimens in Marseille, France: A retrospective analysis, June 25, Travel Medicine and Infectious Disease https://www.sciencedirect.com/science/article/pii/S1477893920302817

References

FDA. 2020. FDA cautions against use of hydroxychloroquine or chloroquine for COVID-19 outside of the hospital setting or a clinical trial due to risk of heart rhythm problems. fda.gov. April 24, 2020. [Cited: April 24, 2020.] http://archive.is/xwOAc.

Gautret, Philippe , Lagier, Jean-Christophe and Raoult, Didier et al. 2020. Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial. International Journal of Antimicrobial Agents. March 20, 2020. https://www.sciencedirect.com/science/article/pii/S0924857920300996.

InCrowd. 2020. Novel Coronavirus COVID-19 Physician Tracking Report. InCrowdNow.com. April 21, 2020. https://incrowdnow.com/wp-content/uploads/2020/04/InCrowd-Novel-Coronavirus-COVID-19-Physician-Tracking-Report-Wave-4.pdf.

Jackson-Coker. 2020. Physicians Poll on COVID-19 Medications. JacksonCoker.com. April 8, 2020. includes https://jacksoncoker.com/about/in-the-news/physician-poll-on-covid-19-chloroquine-and-hydroxychloroquine/. https://jacksoncoker.com/landing-pages/physicians-poll-on-covid-19_medications/.

Our World in Data. 2020. Daily new confirmed COVID-19 deaths per million people, rolling 7d average, Spain & Italy. ourworldindata.com. 2020. [Cited: June 29, 2020.] https://ourworldindata.org/coronavirus-data-explorer?zoomToSelection=true&time=2020-03-09..2020-05-15&deathsMetric=true&dailyFreq=true&perCapita=true&smoothing=7&country=ESP~ITA&pickerMetric=location&pickerSort=asc.

Raoult, Didier. 2020. COVID-19, presentation at GENERAL ASSEMBLY AP-HM CARE AND DIAGNOSIS. mediterranee-infection.com. March 16, 2020. https://www.mediterranee-infection.com/wp-content/uploads/2020/03/COVID-19.pdf.

Risch, A Harvey. 2020. Early Outpatient Treatment of Symptomatic, High-Risk Covid-19 Patients that Should be Ramped-Up Immediately as Key to the Pandemic Crisis. American Journal of Epidemiology. May 27, 2020. https://doi.org/10.1093/aje/kwaa093.

Sermo W3. 2020. Sermo’s COVID-19 Real Time Barometer Study, Wave 3. Sermo.com. April 15, 2020. includes https://app.sermo.com/covid19-barometer, https://www.sermo.com/press-releases/sermo-reports-week-3-results-globally-17-point-increase-in-covid-treaters-who-have-used-hydroxychloroquine-33-50-and-azithromycin-41-58/. https://public-cdn.sermo.com/covid19/dd/c7f7/f7344a/344a00427889ec27e2b8df1c15/w3-sermo-covid-19-barometer.pdf.

Sermo W4. 2020. Sermo’s COVID-19 Real Time Barometer Study, Wave 4. Sermo.com. April 23, 2020. includes https://www.sermo.com/press-releases/sermo-reports-jury-is-still-out-on-remdesivir-31-of-physicians-who-have-used-remdesivir-rate-it-as-highly-effective-31-rate-it-with-low-effectiveness-38-rate-it-as-somewhere-in-the-middle/. https://public-cdn.sermo.com/covid19/c2/3aba/ba8889/88898d406a8a84a60947e34a56/sermo-barometer-banner-tables-wave-4.xlsx.

The National Institutes of Health COVID-19 Treatment Guidelines Panel . 2020. Coronavirus Disease 2019 (COVID-19). covid19treatmentguidelines.nih.gov. April 20, 2020. [Cited: May 1, 2020.] http://archive.is/gk3xt.

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mdman
July 7, 2020 6:13 am

There is a very useful resource for research paper links here:

https://c19study.com

Krishna Gans
Reply to  mdman
July 7, 2020 6:53 am

Thx for the link, poison fir some specialists here 😀

philincalifornia
Reply to  Krishna Gans
July 7, 2020 8:43 am

Yeah, thanks. IMO, the Lagier et al. study, i.e. the very latest paper from the Raoult group is probably the most up-to-date. Singled out here:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315163/

jtom
Reply to  mdman
July 11, 2020 8:07 am

It bothers me when I see figures in a graph that do not correspond to published numbers. If you look at the number of deaths per million, updated on 7/11, the numbers for the US appear to be at about 550 and above France.

We are at 413, and below France, according to the link below for the same date.
https://www.worldometers.info/coronavirus/#countries.

So which numbers are correct?

Scissor
July 7, 2020 6:20 am

Don’t forget to treat early and include zinc (unless the objective is a poor outcome, in which case, adjust data as needed).

Nicholas McGinley
Reply to  Scissor
July 7, 2020 7:39 am

No one should wait to get sick to make sure they have plenty of every nutrient associated with immune system health.
In fact, everyone should know the exact list of all essential nutrients for a human being, and have at least basic knowledge about the role each plays in our body.
No one can be healthy without proper nutrition.
It used to be easy.
But modern food industry and marketing has made it hard for our own instincts…our nose, eyes, and tongue…to tell us what we need, what is good to eat, what is bad, etc.

First biology class I took in college, first semester, human health and reproduction.
Nothing Earth shaking, but detailed and specific knowledge replaced sketchy information with some fine detail but huge gaps.

Krishna Gans
Reply to  Nicholas McGinley
July 7, 2020 8:59 am

Most people don’t know anything about proper nutrition, some a bit. But it’s not so easy to have a proper nutrition, there are many reasons, why. Learning at school is deplorable, missing time for several reasons is mainstream if you are working, or in case of parents, both are working to buy and prepare proper nutriotion in case they know at least a bit about.
Fruits you can buy are mostly unripe with vitamine deficits, vegetables usually come from in general outleached grounds with some mineral deficits.
Working indoors is one reason for vitamine D deficits.
And if you have a look at at least the German Greens, they try to regulate the market for nutrition supplements, because they believe, they are not necessary, to high dosed etc.
As usual, they have no clue of real life and it circumstances.

Krishna Gans
Reply to  Krishna Gans
July 7, 2020 10:30 am

Forgot to mention, short of money is a reason too for mal nutrition.

bonbon
Reply to  Krishna Gans
July 7, 2020 11:55 am

Poverty is a real killer. No healthcare systems and no proper food. The numbers for Africa are horrendous, but Germany is seeing kids malnourished.
The US too. And elderly are systematically vitamin D3 deficient.

The Greens will say let them eat green leaves, drink “natural” water.

Note the recent report on COVID in sewage samples from mar-2019 – just imagine what bad water and sewage treatment will do!

Jeffery P
Reply to  Krishna Gans
July 8, 2020 4:55 am

The poor in America are the most overweight and obese population in the country. There is plenty of money for food, it’s just spent poorly.

Nicholas McGinley
Reply to  Krishna Gans
July 7, 2020 11:39 am

“Fruits you can buy are mostly unripe with vitamine deficits, vegetables usually”

Say what?
Do you have evidence for this?
Ripeness has to do with starch being converted to sugar, and the vitamins are already there.
If the ground in which plants are grown do not have the nutrients plants need, they will not grow.
Even small deficits in mineral concertation will make a plant look very obviously wrong.
Spots, yellow…

Are you really saying that buying fruits and vegetables is a fools errand because they are all crappy?
Are you saying junk food is more affordable than wholesome foods?
The opposite is true in both cases.
Processed foods are expensive, calorie per calorie, compared to wholesome foods.

Where I shop foods are fresh and ripe, unless it is one of the well known ones that cannot be picked and shipped ripe.
Ripe bananas in the tropics will be mush before they get loaded onto the boat to ship them.
Pineapple is far better when picked bright yellow, but they are too soft to ship at that pont.
Except local ones in season, foods like tomatoes are picked green and ripened with ethylene gas to make them turn red.
They have zero flavor.
But all of these things have always been true.

I have been involved in agriculture since the 1980s, and right now have dozens of fruit trees and plants.
But most people do not even grow a garden for fresh greens and herbs during the times of year it is fast and easy to get a garden going.
Laziness and ignorance are the problems, not leached soils and unripened fruit.

Krishna Gans
Reply to  Nicholas McGinley
July 7, 2020 12:55 pm

OMG

Are you really saying that buying fruits and vegetables is a fools errand because they are all crappy?

No, but they could be healthier, could have more minerals, even if not deficient for growing.

Do The Proportions Of Nutrients Change In Fruit As It Ripens?
Updated on: 23 Apr 2020 by John Staughton

When you go to the grocery store and re-stock your house with fruits and vegetables, it’s hard not to feel like you’re making a heathy choice for the week ahead. As we all know, fruits and vegetables are a critical part of a healthy diet, and provide a wide range of essential nutrients, from key vitamins and minerals to antioxidants, sugars and dietary fiber.

I’d be happier if these were snacks memeHowever, as that week progresses, your fruit may continue to ripen, often changing color or firmness over time. Bananas are perhaps the best and most visually demonstrative example of this, but all fruits undergo a ripening process (sometimes on the vine, and sometimes after being picked). This has led many people to wonder whether those physical changes in a fruit also affect its nutritional content. In other words, is there a nutritional difference between ripe and unripe fruit?
Why Do Fruits Ripen?

Before we dig into the details of what happens during ripening, we should take a look at why the process occurs at all. First of all, a fruit is effectively a container for the seeds of a plant, and develops from a flower. Basically, when a flower releases its pollen, this is done in order for other plants to be fertilized. Pollen is taken from the male part of a plant and brought to a female part of the plant. When this is completed, fertilization can begin and the flowers will begin to drop off.

Fertilization leads to the development of plant seeds, which need to be protected as they develop. The fruit that develops around the seeds will provide this protection, while also acting as the distribution tool for the seeds to grow. For example, after fertilization, a fruit will begin to grow around the seeds, but that fruit is said to be “underripe” until the seeds are fully developed and capable of growing into another plant if given the right soil and climatic conditions.

Two weeks ago, I was in a bear’s stomach. memeThe ripening process is a form of growth, as well as a defense mechanism. When a plant is unripe, it will often be sour, overly fibrous, or even toxic to consume. Animals won’t want to eat that sort of fruit, and will therefore leave it alone. Once a fruit becomes “ripe”, it will often be sweeter, more colorful, and generally more appealing to a potential consumer. When the animal eats this sweeter, more attractive fruit—whether it is a bird, squirrel, bear, human or any other creature—it will then deposit those seeds elsewhere, after they pass through their digestive tract or are disposed of on the ground. By that point, the seeds will be viable and can grow into a new plant!
What Does Ripening Do To A Fruit?

As mentioned above, the ripening process often consists of a change in color, firmness and sweetness, all of which can signal that a fruit is ready to be eaten. Those physical changes are also reflected in a nutritional shift, primarily an increase in sugars. Many underripe fruits have a high starch content, which can make the fruit bitter or inedible, but as the fruit ripens, those starch molecules are converted into sugars.

The easiest example of this is a banana; green and underripe bananas do not have the recognizable sweetness and softness of a ripe banana. The conversion of starch into sugar gives the banana a higher percentage of sugar, as well as a better texture for eating and including in recipes. Sugar content is the most notable nutritional change between unripened and ripened fruit, but it’s not the only one. Vitamin C, for example, has been shown to increase as you allow peppers and tomatoes to develop to full ripeness.
In many other fruits, the antioxidant concentration will also improve as a fruit ripens. Considering that these are critically important nutrients for our body’s defenses, particularly against cancer and other forms of oxidative stress, getting more antioxidants in ripe fruit is definitely a good thing!

Source
An other with more examples

Food is not what it used to be. In the past, food was not necessarily always better and certainly not made of wood. But the ingredients tasted different. More intense. More. Radishes were hotter, tomatoes were more sweet and sour and the cauliflower, well, it tasted more like cauliflower. Something seems to have squeezed the taste out of our food over the last few decades.

This impression is more than a feeling, because the composition of our food has changed measurably over the past 50 years. A glance at various editions of corresponding overviews of the chemical composition of our food shows drastic changes: Oranges now contain only one-eighth of vitamin A, broccoli supplies 80 percent less copper, tomatoes have lost three-quarters of their calcium1. Wheat has lost up to half of its mineral content since 18422.

Donald Davis, a biochemist at the University of Texas, reports an average total mineral loss of 5 to 40 percent in fruits and vegetables4. A similar trend is evident for vitamins and protein. The proportion of protein in chicken has fallen by around a third – at the same time the proportion of fat has doubled4.

Accordingly, the market for dietary supplements is flourishing and their effects are not always obvious. However, in experiments with rats, Davis found evidence of subtle changes through better nutritional supply: “The rats supplied in this way ate less, but grew slightly better “5 The observations continued to include better wound healing, better regeneration and effects on sugar consumption.
This supports the thesis that people in Western societies are starving to death despite the spread of obesity: energy supplies are amply ensured, but there is a lack of micronutrients (vitamins and minerals). It is part of the normal bodily functions to report hunger in this situation, some people perceive this as ravenous hunger. This is therefore not only the result of incorrect sugar management. It is a logical consequence: you have to eat more to get the same amount of nutrients.

Is this a reason to get food supplements quickly? Hardly. This observation should not cause panic among those who eat a variety of fresh foods, because they are usually well supplied despite weakening plants. However, people with a rather monotonous diet based on pre-processed food and those living in areas with poor food supplies are faced with this development.

Beyond the purely reductionist perspective of nutrientism, there is also a worrying look at taste, which is directly linked to the nutrients it contains. Taste is not only the driving force behind nutrition, but an expression of our culture and thus of our identity. That is why people in the better supplied regions also need a solution to this problem. We are not all in the same boat in this respect, but we are in a small fleet called humanity. And even for those at the top, the wind will no longer be enough at some point.
First we need to understand the cause of the phenomenon. Since plants draw their nutrients from the soil, it is often hastily argued that the cause is leached soil7 . It is true that conventional agriculture, including the Green Revolution, has led to massive fertility loss and soil degradation worldwide, especially in the last 50 years. Anyone who has bought and eaten the goods produced in this way is responsible for this damage, and in the final analysis we all are. However, a differentiated consideration points to more than depleted soils.

Davis cites an environmental dilution effect. Intensive fertilization and irrigation lead to higher yields, but “the ability to produce or absorb nutrients could not keep pace with the rapid growth,” as agronomists have known since the early 1980s8.

Breeding varieties with higher yields, better pest resistance and increased climate adaptation also leads to a genetic dilution effect: higher-yielding varieties thus contain proportionately fewer nutrients under the same growth conditions.

The use of crop protection products also reduces the amount of antioxidants. Organically produced foods contain more of these secondary plant substances, which is attributed to the greater stimulus for the plant’s self-protection.

If soil fertility, environmental and genetic dilution effects and the use of pesticides are the reason for the declining nutrient content of our food, then the signs clearly point to the methods of agriculture as the cause. The methods of conventional agriculture.

However, this finding does not release the consumer, the consumer, from responsibility. “Eating is an agricultural act, we are all farmers by proxy,” explains farmer and author Wendell Berry. We may hand over the work and pay for it, but we are responsible for the production. We “can only eat if land is farmed in our name somewhere in some way.”

Source, German

Not everybody has a garden as we have it, and is able to grow the plants they want or need, as you state at least correctly.

hiskorr
Reply to  Nicholas McGinley
July 7, 2020 2:02 pm

Don’t get your shorts in a twist. The “nutrients plants need to grow” and the “nutrients animals/omnivores/humans need to get from those plants” are not identical. Large Venn overlap, but not 100%. Commercial farmers must cater to the plants’ needs. It’s up to us humans to look out for the rest. Laziness is not necessarily the problem with city beehive dwellers. Ignorance and misinformation propagated by FDA and DoAg surely is a problem.

Krishna Gans
Reply to  Nicholas McGinley
July 7, 2020 3:05 pm

You want more ?

In 1927 a study at King’s College, University of London, of the chemical composition of foods was initiated by Dr McCance to assist with diabetic dietary guidance. The study evolved and was then broadened to determine all the important organic and mineral constituents of foods, it was financed by the Medical Research Council and eventually published in 1940. Over the next 51 years subsequent editions reflected changing national dietary habits and food laws as well as advances in analytical procedures. The most recent (5th Edition) published in 1991 has comprehensively analysed 14 different categories of foods and beverages. In order to provide some insight into any variation in the quality of the foods available to us as a nation between 1940 and 1991 it was possible to compare and contrast the mineral content of 27 varieties of vegetable, 17 varieties of fruit, 10 cuts of meat and some milk and cheese products. The results demonstrate that there has been a significant loss of minerals and trace elements in these foods over that period of time. It is suggested that the results of this study cannot be taken in isolation from recent dietary, environmental and disease trends. These trends are briefly mentioned and suggestions are made as to how the deterioration in the micronutrient quality of our food intake may be arrested and reversed.

A Study on the Mineral Depletion of the Foods Available to us as a Nation over the Period 1940 to 1991
Full study

Krishna Gans
Reply to  Nicholas McGinley
July 7, 2020 3:08 pm

New government statistics show fresh fruit and vegetables are not as good for us as they were 60 years ago. The report, by nutritionist and chiropractor Dr. David Thomas, shows the content of natural minerals, such as iron, calcium, copper and magnesium, has decreased by up to 76 per cent since 1940. The growth of intensive farming methods, which use artificial fertilizers to get plants to grow bigger and faster, is blamed for the decline.

Dr Thomas said: “The findings suggest that our diet is now far less nutritious than it was 60 years ago. It is likely that levels of a whole host of other trace elements which have proven benefits to health and whose absence can create disease conditions, have also been depleted. “Nowadays you need to eat three times as many oranges as you would have done in 1940 to get the same amount of iron. Dr Thomas compared statistics for the mineral content of fruit and vegetables in 1940 with the latest figures from 1991.

In the vegetables the level of magnesium had dropped by nearly 25 per cent, calcium by 46 per cent and sodium by 50 per cent, while copper levels had slumped by more than 75 per cent. In fruit, sodium had dipped by 27 per cent, iron by 25 per cent and copper by 20 per cent.

A lack of iron can impair intellectual functions, while calcium is vital for strong teeth and bones, particularly in children. A shortage of magnesium can lead to neurological and heart problems.

Although modern intensive farming allows fruit and vegetables to grow faster as they receive lots of nutrients, it does not necessarily create produce with the same amount of minerals as in previous generations. A greater number of crops growing in one area means less nutrients from the soil per plant.

Mike Lean, professor of nutrition at Glasgow University who is also a director of the Health Education Board for Scotland, said: “Advice at the moment is to eat a minimum of five portions of fruit and vegetables combined every day. Maybe we should be eating considerably more than that.

New UK Study Shows Decline in Fruit
and Vegetable Mineral Content
This section is compiled by Frank M. Painter, D.C.

Enough ?
Go in your garden and play around 😀

ex-KaliforniaKook
Reply to  Nicholas McGinley
July 7, 2020 5:50 pm

Nicholas,
Almost everything you say is correct. There are a lot of greenies out there who will tell you something was better in the past. Food is one of them They usually give organics a pass from such judgement. I still remember as a kid watching some of the neighboring farms that grew organically. Unlike us, those farmers wore environmental suits suits while working the fields, and rode in enclosed tractors with AC – still in those outfits. Because what they were spraying on those fields was more safer than what we were using…?! There is a reason organic food does not usually look as good as “Non-organic” food (an oxymoron, as any chemist knows). When organic food does look as good as non-organic, check the nation of origin. It’s usually China. They don’t allow American inspectors on their farms.

American farmers have been rotating crops since the 40’s. I understand that some areas of the world don’t do that. DON”T EAT THEIR FOOD!

My wife is an animal rights activist. I remember her showing me a photo a couple of years ago of a guy who had gone into a wolf or coyote den to kill the pups. He then posed with his trophies. I told her that photo was ancient. She contacted the source (ASPCA donation drive). They confirmed that the event had taken place in the 1940’s, and the man worked for the Government. They had no newer pictures, but assured her the Government was still doing this, and her donation could help stop this barbarous activity.

The data about American-farmed food having fewer minerals is just as valid. We did prefer the food Grandpa and Uncle Bob had grown versus the grocery store – it was fresher. Greenie scientists extrapolate the mineral content from the past using models. Hm. Who else does that?

And to this day, I will not touch “organically-grown” food. The stuff they can put on it is dangerous. Just look at those environmental suits. They are not to protect the food from the farmer.

Yirgach
Reply to  Nicholas McGinley
July 8, 2020 5:06 am

I apply Azomite rock dust to the garden every spring before planting.
Been using it for several years now.
The stuff makes a noticeable difference in the taste and appearance of all the vegetables.

See https://azomite.com/azomite-home-page/frequently-asked-questions-about-azomite-mineral-products/

Krishna Gans
Reply to  Nicholas McGinley
July 8, 2020 8:59 am

@Yirgach
We use so called powdered limestone, hornshavings and compost from our heap.
And we add smal pieces of wood charcoal remaining from last BBC.

AndyHce
Reply to  Nicholas McGinley
July 9, 2020 5:13 am

Most people have no place to plant anything.

scissor
Reply to  Nicholas McGinley
July 7, 2020 9:04 am

Today, discussing nutrition might be seen as racist. /s

Krishna Gans
Reply to  scissor
July 7, 2020 10:52 am

Counter question: what is not racist ? /sarc

bonbon
Reply to  Krishna Gans
July 7, 2020 12:10 pm

How about Susan Ricist?
Lookin’ to run with Biden, and well, blow the planet up.

icisil
Reply to  Krishna Gans
July 7, 2020 6:06 pm

OK, you opened the door, so I have to post this now because it’s one of the funniest things I’ve seen lately. This is the man running against Trump.

https://twitter.com/FogCityMidge/status/1255245341886218241

Gary Pearse
Reply to  Scissor
July 7, 2020 10:05 pm

So 85 % of doctors globally used HCQ but only 43% in America. I think if I ever got sick I would ask who my doctor voted for before handing myself over for treatment. Just sayin’

Samuel Saunders McAllister
July 7, 2020 6:41 am

My GP has said he will prescribe the HCQ /Azith/ Zinc group if I contract Covid-19 particularly after being tested. I am in the senior citizens age group. When I spoke to him about this treatment it was like “You may very well say that but I could not possibly comment” and so he agreed to write a prescription if the time came, because he is fully aware of the survival rates from it.

icisil
Reply to  Samuel Saunders McAllister
July 7, 2020 7:32 am

For those whose doctors won’t prescribe HCQ, make a reservation for a weekend trip to a malaria-infested country and demand the doctor give it to you for that.

Latitude
Reply to  icisil
July 7, 2020 9:12 am

Or just go across the southern border…..and buy it over the counter

hiskorr
Reply to  Latitude
July 7, 2020 2:15 pm

Or some Chinese chalk that is marked the same way.

Dave Fair
Reply to  hiskorr
July 7, 2020 2:19 pm

Great whit, hiskorr.

ex-KaliforniaKook
Reply to  hiskorr
July 7, 2020 6:08 pm

I second Dave!

Krishna Gans
July 7, 2020 6:42 am

NMG will tell us in thousands of words that the studies are all flawed and/ or meaningless, because he just found a study that…..

Nicholas McGinley
Reply to  Krishna Gans
July 7, 2020 7:40 am

I am all up in your head, aren’t I?
Cupcake, you have no idea how big that makes me smile.

Krishna Gans
Reply to  Nicholas McGinley
July 7, 2020 9:05 am

You ? 😀 😀 😀
Don’t be to proud of yourself as if I mention you in a positive way.
You are the best example of what a negative one is 😀

DocSiders
Reply to  Nicholas McGinley
July 7, 2020 9:36 am

Pretty sure you don’t exist anywhere in reality.

And…Leftist never smile….that was a leftist lie. Leftists always lie.

Nicholas McGinley
Reply to  DocSiders
July 7, 2020 11:50 am

I’ll have to take your word for it.
One thing is for sure and everyone knows it: @$$holes will be @$$holes.

Thanks for my daily reminder.

mario lento
Reply to  Nicholas McGinley
July 7, 2020 12:13 pm

Nicholas: Perhaps Krishna is being too kind, so that you misinterpret, as you are want to do.

When people see cockroaches, rats, house flies, and bats at a wet market, the informed look in disgust because of what’s in their heads.

That is how in our heads…

Nicholas McGinley
Reply to  Krishna Gans
July 7, 2020 7:45 am

It also tells everyone you have no idea what people are saying, because you do not listen, do not read, do not recall…
In any case, this is not a study, it is a survey.
Might as well call a poll a study.
John Cook called his “work” a study too.
But this is from April, when no one knew as much as they do now.
I happen to know that they are still polling people.
I have not looked at them for a while, but I will now go and see how polls from right now look.
Not because I find them to be highly compelling, but because obviously what people think now is derived from more information and experience than ones taken last April.
Have you learned anything new since April?

Krishna Gans
Reply to  Nicholas McGinley
July 7, 2020 8:28 am

Have you learned anything new since April?

Not from your comments, be sure 😀

Clyde Spencer
Reply to  Krishna Gans
July 7, 2020 2:35 pm

Gans
I don’t feel that you are contributing anything substantive to the dialog. Your forte seems to be insults to those who hold a different opinion. How about trying to attack the statements with logic and facts instead of attacking the person?

It has been my experience that Nicholas has contributed more in the way of information and analysis than most here. I wish I could say the same about you. I wouldn’t be any more ignorant if you had never posted anything.

Let me ask you a question. What are the chances that some obscure doctor who published early, that no one had heard of before the pandemic, would come up with the right dosage of a drug never before used for this disease, and the right amount of time to take the drug? Consider that the dosage and amount of time to take a drug are usually an essential part of early trials for new treatments. Now this doctor just might be Sherlock Holmes’ smarter brother — Shear Luck — but, it seems improbable to me. HCQ just might turn out to be the best thing in the world for COVID-19; however, at this point in time, the evidence for that is very poor. Those who promote it based on anecdotes and small, non-random trials are not scientists. They are in the same category as those who avoid black cats and throw salt over their shoulders after spilling some.

mario lento
Reply to  Clyde Spencer
July 7, 2020 2:46 pm

“What are the chances that some obscure doctor who published early, that no one had heard of before the pandemic, would come up with the right dosage of a drug never before used for this disease, and the right amount of time to take the drug?”

Well a doctor should be able to understand how to get information on a drug that has been around for over 60 years. So I don’t but that assertion. Sars was like 1.5 decades ago and there is a plethora of medical information about Chloroquine at known safe doses that were proven to be effective.

The bad studies, most of which failed, show the worst of society. The people who want there not to be a cheap cure are evil at best. I am not saying I know which people are evil…

Dave Fair
Reply to  Clyde Spencer
July 7, 2020 4:01 pm

HCQ+ is cheap, safe and has some evidence it helps if taken early, Clyde. Why don’t you just jump on a different TDS horse? My review of the study “proving” HCQ causes heart troubles showed it was a pile of steaming ideological crap. Any supposed scientist or medical practitioner supporting it is/was a liar.

After my WuFlu diagnosis yesterday, I will be taking HCQ+ one way or another. At age 72, I’ve learned my reasoned judgement is usually right-on. Listening to ideologues or representatives of special interests (as you apparently are one or the other) always gets one in trouble or costs one alot of money (even poverty), usually both. And death is not an uncommon outcome.

I’ve closely followed the arguments on every side of the various ChiCom virus and WuFlu debates since day one. They have all degenerated into ideological debates driven by misinformation from ChiCom, WHO and other politicized sources. The mere fact that those sources do not clearly inform reviewers that the results from their studies are based on application of HCQ to near-terminally ill patients indicates they are deliberate propaganda.

Screw off, Clyde.

mario lento
Reply to  Dave Fair
July 7, 2020 4:04 pm

But Dave:
Can’t you just be patient, and wait another 4 months? There’s a respirator there you can use too…

Of course that was sarcastic… Be well, and good luck sir. Keep up the vitamin D too.

Dave Fair
Reply to  mario lento
July 7, 2020 4:44 pm

Thanks, Mario! Sarcasm aside, at no time is anybody shoving that tube down my throat. I’ll do everything in my power to avoid that fate. Clyde has no common sense.

mario lento
Reply to  Dave Fair
July 7, 2020 4:59 pm

I as one would not dare! 🙂 You are a fighter… and you will be fine, I can (unscientifically) feel it.

Dave Fair
Reply to  mario lento
July 7, 2020 5:14 pm

You might be more correct than you know, Mario. If I ever get a chance, it would be fun to tell you how I went back to Fresno, CA a week later to successfully retrieve my stolen, future-champion Pug dog. I usually accomplish what I truly set my mind to. I appreciate your good feelings towards me, Mario.

mario lento
Reply to  Dave Fair
July 7, 2020 5:28 pm

Hey, I would love to take that off line. Would be a great story to hear. Your situation certainly gives you a pass by the way, on your colorful language… and that your responses are well reasoned, regardless of whether people agree with your thought process. I just so happen to align…

Krishna Gans
Reply to  Clyde Spencer
July 7, 2020 4:08 pm

If you mean with “obscure doctor” Didier Raoult, than be aware that he isn’t certainly not as obscure as you belive. He is what everybody calls a specialist and / or expert
And his studies and trials are based on earlier successful trials of treatment in China.
So he had a base for dosage and time amount.
And in the beginning, they were always testing the viral load and find out, how long to treat.
Btw. these studies have been discussed here iin earlier times and, as published on google docs, days later, they disappeared.

Reply to  Clyde Spencer
July 7, 2020 5:22 pm

Dave Fair,
Right on! All the stuff I have seen corroborates what you said. All this anti-HCQ propaganda is TDS on steroids. We old folks should use it immediately and don’t forget the zinc.

mario lento
Reply to  Dan Pangburn
July 7, 2020 5:42 pm

But you old folk tend to be Trump voters, that is motivation enough to believe the opinion articles disguised as science… [disclaimer OK I have always gravitated towards older folks, shoveling snow as a kid, talking to older neighbors and grandparents when I could. The wisdom attracted me. I am 55, I am getting close myself… can’t wait!]

So they poo poo good anecdotal and better than anecdotal results because they did not follow a practice that someone needs to fund at great expense, while people die. And then if a study is funded, and runs filled with bad data that will later need to be retracted… that’s fine. Because it’s on CNN, and the MSNBC, NYTimes or the CDC or WHO said so.

Dave Fair
Reply to  Dan Pangburn
July 7, 2020 5:46 pm

Biden notwithstanding, old folks are not stupid nor easily mislead. My reference to HCQ+ means a combination of HCQ, AZ and zinc. It seems to be the ideal combination in the relevant studies.

Even at age 72, I did not seek to take HCQ+ until yesterday’s diagnosis of WuFlu. I think its use as a prophylactic should be saved for those in higher risk categories; the elderly with high blood pressure, diabetes, heart problems, obesity, etc. Having said that, I also believe that people should use their own judgement on taking HCQ+.

Good luck, Dan. Hopefully we come out of this politicized mess stronger as a people.

RG
Reply to  Clyde Spencer
July 7, 2020 9:05 pm

We have a winner of the title: Parrot of the Day

Nicholas McGinley
Reply to  Clyde Spencer
July 8, 2020 11:47 am

Thanks Clyde.

Reply to  Clyde Spencer
July 8, 2020 1:28 pm

Dave,
I agree again, completely. My mistake for assuming immediately meant immediately on testing positive.

Nicholas McGinley
Reply to  Clyde Spencer
July 10, 2020 6:30 am

Breaking news moving world markets.
Experimental treatment reduced mortality by 62% in vivid patients:

“- Data Presented Includes a Comparative Analysis of Clinical Recovery and Mortality Outcomes from the Phase 3 SIMPLE Trial Versus Real-World Cohort of Severe COVID-19 Patients Receiving Standard of Care —

— Traditionally Marginalized Racial/Ethnic Groups Treated with Remdesivir Had Similar Clinical Outcomes as Overall Patient Population —

FOSTER CITY, Calif.–(BUSINESS WIRE)– Gilead Sciences, Inc. (Nasdaq: GILD) today announced additional data on remdesivir, an investigational antiviral for the treatment of COVID-19, adding to the available body of knowledge on treatment outcomes with remdesivir. The data are being presented at the Virtual COVID-19 Conference as part of the 23rd International AIDS Conference (AIDS 2020: Virtual) and include a comparative analysis of the Phase 3 SIMPLE-Severe trial and a real-world retrospective cohort of patients with severe COVID-19. In this analysis, remdesivir was associated with an improvement in clinical recovery and a 62 percent reduction in the risk of mortality compared with standard of care. “

Bob boder
Reply to  Nicholas McGinley
July 7, 2020 9:03 am

how many different names have you used on this site Mcginley?

Nicholas McGinley
Reply to  Bob boder
July 7, 2020 11:44 am

Back when I had to worry about being doxxed at work for being wrong on global warming, I used the handle Menicholas.
Since then I have used my name.
Something on your mind, boder?

One might think that anyone who wonders about that probably has sock puppets.
Are you concerned I slipped a comment in under your nose?

Bob boder
Reply to  Nicholas McGinley
July 7, 2020 3:02 pm

Lol, couldn’t care less what you do or don’t do.

Nicholas McGinley
Reply to  Nicholas McGinley
July 8, 2020 5:42 pm

You are very curious and ask a lot of questions for someone who does not care.

Krishna Gans
Reply to  Nicholas McGinley
July 7, 2020 9:10 am

You didn’t realise, the poll was about studies, and I spoke about these studies, never mind 😀
But you tell me, I don’t read, nice 😀 😀 LOL

Clyde Spencer
Reply to  Nicholas McGinley
July 7, 2020 10:52 am

Nicholas
I read a poll that said Hillary will win the 2016 election. Must be true! 🙂 Funny how climate skeptics disparage consensus, but those pushing HCQ use it as their main support.

There have been so many different drugs tried, all showing some apparent benefit, that I think anyone with an open mind should consider the placebo effect as playing a role in all this.

Krishna Gans
Reply to  Clyde Spencer
July 7, 2020 11:13 am

Is there any consensus about HCQ ??
Not really, or did I miss s.th. ?
Btw, in questions of climate, there is s.th. like a skeptical consensus 😀
You can’t compare the one with the other if you are open minded (enough) 😀

Nicholas McGinley
Reply to  Krishna Gans
July 7, 2020 12:09 pm

I do not know about concensus, but I have noticed that ever since I made some comments that you disagree with about HCQ, you have not stopped saying my name, and making dumb replies to every comment I make.
Today the only thing on your mind, hours before I got here, was what I was going to say.

One thing you never do, and I mean NEVER…EVER…is read a comment, and then respond to someone in an intelligent manner, even if you disagree with them, even if they just have a random question.
Ever.
You have no idea how to read something, consider what is being said, and offer some thoughts in the manner of a conversation.

I liked you better back when you were a credulous, gullible, admittedly scientifically illiterate, and more or less a somewhat pleasant person.
Remember the day you learned that malaria was not a virus?

https://wattsupwiththat.com/2020/03/17/an-effective-treatment-for-coronavirus-covid-19-has-been-found-in-a-common-anti-malarial-drug/#comment-2940060

Krishna Gans
Reply to  Krishna Gans
July 7, 2020 3:17 pm

I re-learned the fact, as while commenting I in fact forgot it, point

For the rest:
You get out what you put in.

Krishna Gans
Reply to  Clyde Spencer
July 7, 2020 11:22 am

PS
You forgot
Mainstream vs climate skeptics
Mainstream vs use of HCQ

Krishna Gans
Reply to  Clyde Spencer
July 7, 2020 11:40 am

Virae prohibited to replicate is usually not to reduce on a placebo effect 😀
But maybe, Corona is a placebo ? 😀

Ted
Reply to  Nicholas McGinley
July 7, 2020 12:04 pm

In early April, the doctors knew the outcomes they had seen, and there was no political motivation to push results one way or the other.

Krishna Gans
July 7, 2020 6:47 am

No idea what to think about infos coming from Turkey, where everybody with symptoms is treated with HCQ, and have a lower death rate than Germany, in total and in relation to population.

bonbon
Reply to  Krishna Gans
July 7, 2020 12:13 pm

Erdogan, while trying for a new Caliphate in Libya, threatened to allow infected migrants through. I’ll withhold judgement on any Turkish stats.

DMacKenzie
July 7, 2020 7:03 am

Goldstein publishes more of his personal interpretation of studies of studies of medical rumours here on WUWT. Can also be interpreted as 85% of physicians administering HCQ feel it is a positive psychological crutch at fairly low cost for patients wanting the best meds possible, even if they don’t really work. Pretty soon we should be up to the indisputable 97% consensus that it does something good/bad which we have heard before.
Just search on “HCQ ineffective” for an instant Goldstein rebuttal…..

Krishna Gans
Reply to  DMacKenzie
July 7, 2020 7:16 am

Just compare the differences in protocols the studies you prefer in contrast to the studies of L. Goldstein or mdman above linked.

Nicholas McGinley
Reply to  Krishna Gans
July 7, 2020 12:15 pm

Maybe you could say exactly what it is you want to say?
What protocols are you referring to?
Which are the good ones, and why?
Which ones are not as good, and why?
Are you capable of that sort of communication?
Or are you just a little girly man who pretends to know sh!t from shinola after a few months of internet echochambering?

I think the warnings about the estrogenic properties of all that quercetin you are gobbling up has had the desired effect.
Growing tits yet, or is it all behavioral at this pint?

Krishna Gans
Reply to  Nicholas McGinley
July 7, 2020 3:21 pm

I never wrote about steroids or quercetin, learn to read comments, and wrote about what.

Nicholas McGinley
Reply to  Krishna Gans
July 7, 2020 8:28 pm

You never wrote about quercetin?
Is that what you said?

*rolls the eyes*

Steroids was part of the protocol that was changing over time.
You babbled something about comparing the protocols.
Try to keep up.
Was it a three drink lunch again?

whiten
Reply to  DMacKenzie
July 7, 2020 1:43 pm

DMacKenzie
July 7, 2020 at 7:03 am

It is a free choice world, supposedly… so if by any chance you consider a treatment for COVID-19, at some point in time,
please don’t take QHC, and maybe better do consider a seasonal flu vaccination, best a cocktail one, for a further boosting of your immune system, when at it.

It will be great if you manage to persuade also likes of Fauci and Billy Gates of this world to take the same route.

It will be and make it easier for all concerned, I think.

cheers

DMacKenzie
Reply to  whiten
July 7, 2020 4:38 pm

Whiten, everything you mentioned doesn’t do anything substantial for Covid19, or any coronavirus for that matter, so my choice WILL be to NOT take them for that purpose. The annual flu vaccine is worth it for flu. In Didier’s original HCQ study of 26 patients, 6 quit the treatment due to adverse reaction to the HCQ. Like you say, free choice…..

Dave Fair
Reply to  DMacKenzie
July 7, 2020 4:58 pm

Get back to us if you catch the ChiCom virus’ WuFlu, DMacKenzie. Let us know what you think of HCQ+ then. Since my diagnosis, I don’t have a sense of humor about high-minded rationalizations.

DMacKenzie
Reply to  Dave Fair
July 7, 2020 8:10 pm

I haven’t lost faith in my immune system. All the studies point to quite high recovery rates. /s

CBeaudry
Reply to  DMacKenzie
July 7, 2020 7:59 pm

@DMacKenzie No, 6 did not quite due to adverse reactions to HCQ.

Maybe you need to re-read the study if you even did in the first place.

Here are the reasons :
“Six hydroxychloroquine-treated patients
were lost in follow-up during the survey because of early cessation of treatment. Reasons are
as follows: three patients were transferred to intensive care unit, including one transferred on
day2 post-inclusion who was PCR-positive on day1, one transferred on day3 post-inclusion
who was PCR-positive on days1-2 and one transferred on day4 post-inclusion who was PCRpositive on day1 and day3; one patient died on day3 post inclusion and was PCR-negative on
day2; one patient decided to leave the hospital on day3 post-inclusion and was PCR-negative
on days1-2; finally, one patient stopped the treatment on day3 post-inclusion because of
nausea and was PCR-positive on days1-2-3.”

Besides, that was only his very preliminary study, that he shared with the world, so others could also help determine if they would have similar results. Unfortunately, it would seem, they went on attack to try to discredit him instead of doing science.

He followed up with a study of 80 patients, then with another of over 1000 patients, and finaly with one of 3700+ patients.

This is the last one.

https://www.sciencedirect.com/science/article/pii/S1477893920302817

DMacKenzie
Reply to  CBeaudry
July 7, 2020 8:35 pm

CBeaudry,
Death and/or ICU 93 2.5 35 1.1 58 9.4 <0.001 37 17 <0.001 3 3 0.1149 13 9.5 <0.001 5 3.1 0.0449
It’s a fine study, and I do not wish to denigrate the work that many people put into it…..
But look at, for example “Death and or ICU” numbers…..in percentages there is just no real difference whether 2.5 people out of a hundred died or 1.1 died or 3.1. There are many possibilities why sick people don’t recover and a percent doesn’t cover it. Also note the recovery times. Again a day is really insignificant. I’ve waited longer than that in hospitals to be released.

Nicholas McGinley
Reply to  CBeaudry
July 8, 2020 9:49 am

You are right, D McKenzie.
Any differences in the CFR can be easily shown to be either statistically insignificant, or the result of triaging patients prior to treatment.

If 100 people get the virus, and the ones who get very sick go to an ER, and the ones who get somewhat sick go to an outpatient care physician, and the outpatient care physician treats all of those people, then the results of that treatment cannot be compared to the set of all people who got the virus.
Because the worst off ones were removed by going to the ER!

And this is one of the reasons why without blinding and randomization, comparative studies about effectiveness OR efficacy are not scientifically valid.
There are many decades of examples of the proof of this.

It has been correctly state here and on other threads on this topic many times.
Many of the people who refuse to accept this principle are not operating on the level of science, but on the level of political considerations, or refusal to be persuadable.

Perhaps the most powerful force operating on many people regarding this and other such issues is pride and ego.
There are a lot of people in this world who do not wait for enough evidence to be available before making up their minds about some important issue.
If and when they have grabbed onto position or view or opinion which is factually incorrect, they will not be willing or able to admit it or to change their mind.

Too many people have made up their minds without all the facts in hand.
They are now doomed, and we with them, to remain locked into ignorance of the truth.

Kevin A
Reply to  CBeaudry
July 9, 2020 8:58 am

Thanks for the link, the results:
“Conclusion

Although this is a retrospective analysis, results suggest that early diagnosis, early isolation and early treatment of COVID-19 patients, with at least 3 days of HCQ-AZ lead to a significantly better clinical outcome and a faster viral load reduction than other treatments.”

The current issues is the on going TDS DNC talking points along with the cancel crowd rampant activities on anyone that publishes HCO-AZ positive results. Yesterday my local newspaper used an AP (DNC talking points) article that was unbelievably slated to discredit HCO: https://www.ksl.com/article/46774017/brazils-president-bolsonaro-tests-positive-for-coronavirus
Need less to day they did not publish my post about their use of DNC talking points.

Kevin A
Reply to  CBeaudry
July 9, 2020 8:59 am

Needless to say !

Nicholas McGinley
Reply to  CBeaudry
July 9, 2020 9:25 am

HCQ advocates are saying hard core conservatives, such as myself for example, are suffering from TDS.
Now the claim is that any result contrary to what HCQ fans want to believe, is DNC propaganda?

The upshot is, anyone who is not a leftist needs to hitch their wagon to a favorable outcome of clinical trials for HCQ curing COVID?

I sure hope this does not represent a widespread attitude.

whiten
Reply to  DMacKenzie
July 8, 2020 1:39 pm

DMacKenzie
July 7, 2020 at 4:38 pm

Many, you have no idea how idiotic, brain dead zombie, silly crazy stupid, this statement of yours is:
“The annual flu vaccine is worth it for flu.”

Completely stupid in steroids.

One of them givens is a natural proper persisting conditions, the other is simply a clause of stupidity in steroids.

Seasonal flu is a natural cyclic persistence, in consideration of at very least, of 100+ different viral infection diseases, periodic, seasonal, where the stupid humanos like you and me, but not only, are periodically subjected to the natural force of more than 100+ different viral infections disease’s force… of nature, of the life condition.

How much your silly seasonal flu vaccination against such does cover!

Tell me, 2%, 5%, or maybe 10%, at most!

Tell me stupid.

How does it suppose to work?

How much the flu vaccines work or impact against the natural force and power of seasonal flu.???

Let me tell you… nada, nilch zilch.

Only thing such vaccines do is upset the equilibrium of life, by causing an IDS condition in the prospect of herd immunity.

That the only worth of seasonal flu vaccines!

The main life code in the core of this novel corona virus, is far far much older than me you, Fauci, Billy Gates, or even all of us put together at 7 to 8 billion humanos.
Is millions and millions of years older than humanity itself.

Has being there many many millions of years before humanity.

You sillies think it can be stopped or blocked and controlled by face masks or insane lockdowns….please do think again.

cheers

Ron
Reply to  whiten
July 8, 2020 7:24 pm

Seasonal flu is a natural cyclic persistence, in consideration of at very least, of 100+ different viral infection diseases

Wrong. You are confusing common cold viruses with influenza. Completely different viruses.

whiten
Reply to  whiten
July 9, 2020 9:09 am

Ron
July 8, 2020 at 7:24 pm

Ron, completely failing your point made!

All them little badies are “seasonal”, or are them not?????
And related to the same organ almost all.
Ron!

cheers

Ron
Reply to  whiten
July 9, 2020 1:24 pm

@whiten
What season is then the best vor SARS-CoV-2?

Summer? Like the southern states are showing right now.

Winter? Like in China.

Spring? Like in Europe.

The cold and flu do not damage your f***ing kidneys and clotting your blood to induce strokes and thrombosis.

whiten
Reply to  whiten
July 9, 2020 2:12 pm

Ron
July 9, 2020 at 1:24 pm

The cold and flu do not damage your f***ing kidneys and clotting your blood to induce strokes and thrombosis.
——————-

Exactly “little dancing boy”. 🙂

A condition or syndrome called IDS does that, easy.
Especially badly and deadly when non natural in origin.

Good.

You going around and still coming around, with your “dancing”.

🙂

cheers

whiten
Reply to  whiten
July 9, 2020 2:34 pm

Ron
July 9, 2020 at 1:24 pm

Summer? Like the southern states are showing right now.

Winter? Like in China.

Spring? Like in Europe.
———————

Ron, the main point of the questions you posed is simply matter of dumbness and illiteracy.

Not understanding the point of “panic”.
Will be the same with the consideration of seasonal flu versus this new corona virus.

The difference in the clause is the panic… instilling of fear, by any means possible.

If panic the same as per normal seasonal flu, the picture will be the same, dummy.

Simply choice of tracing it or not as for more panic to be produced.

Whichever way considered, the further tracing of this novel corona virus as happening, persist only due to panic and fear… it is not any more in its peak infectious disease epidemic vector for almost all countries or herds in consideration.

It is simply basically applied as a scare mongering story, at this stage, Ron.

Can you understand this simplicity!!!!!

If the same method approach applied for seasonal flu epidemics, and followed ever so thoroughly the same picture will arise.
Is not like we ever done this before for seasonal epidemic influenza…
it is a first, in only one aim, scare the shite out of you, and with no regard or responsibility… Ron.

Some record like this about a seasonal epidemic influenza does not exists there yet because we never before this went so far as becoming so crazy, insane and self destructive.

cheers

Steve Case
July 7, 2020 7:04 am

Hmmm, since this hydroxychloroquine treatment for Covid-19 first appeared for me at least on Dr. Roy Spencer’s webpage March 18th and sometime later we found out that hydroxychloroquine is routinely prescribed for Rheumatoid Arthritis & Lupus, it would be interesting to see the rates of Covid-19 infection for those Lupus and Rheumatoid Arthritis patients compared to the population at large.

Ron Long
Reply to  Steve Case
July 7, 2020 7:51 am

That’s also the data I want to see, Steve, does the group already under treatment with hydroxychloroquine show clear evidence of protection against either incidence or severity of Covid-19?

Red Blooded Haematologist
Reply to  Steve Case
July 7, 2020 8:45 am

Zhong et al. Lancent Rheumatology, 10.1016/S2665-9913(20)30227-7 (Peer Reviewed)
COVID-19 in patients with rheumatic disease in Hubei province, China: a multicentre retrospective observational study
Rheumatic disease patients on HCQ had a lower risk of COVID-19 than those on other disease-modifying anti-rheumatic drugs, OR 0.09 (0.01–0.94), p=0.044 after adjusting for age, sex, smoking, systemic lupus erythematosus, infection in other family members, and comorbidities. 43 patients with rheumatic disease and COVID-19 exposure.

A C Osborn
Reply to  Red Blooded Haematologist
July 7, 2020 1:47 pm

Yes and in Italy a survey of 65000 lupus & arthritis patients, only 20 caught COVID-19.
https://www.jpost.com/health-science/italian-scientist-says-she-discovered-main-mechanism-behind-covid-19-626737

Near the bottom of the report.

Hocus Locus
Reply to  A C Osborn
July 8, 2020 7:04 am

That “only 20 out of 65,000” is a smoking gun if true but I’m afraid the gun was loaded with blank cartridges.

Chiusolo was just repeating — possibly originating — some rumor that was mysteriously circulating in the beginning of May. That round 65,000 number was suspicious in itself… I thought then, if she knows the precise number of patient positives and presumably has access to an accurate number of patients, why only share such a preposterous estimate as “65,000”?

It may be she misspoke during the interview or was misquoted by the Jerusalem Post. Derek Lowe consulted the Global Rheumatology Alliance directly on May 4 articleand they were tracking only 11,762 patients worldwide. He was unable to source the 20/65000 ratio.

Reply to  A C Osborn
July 9, 2020 12:51 am

“Yes and in Italy a survey of 65000 lupus & arthritis patients, only 20 caught COVID-19.”
The link is to a newspaper report only, and it is completely wrong.

From Science:
“The number is completely fictional. As mentioned here in the comments, the president of the Italian Rheumatology Society was contacted directly and states that this number is completely wrong, that the society is monitoring 150 patients in its registry, 20 of whom are taking hydroxychloroquine. The 65,000 number is bogus.”

Hokey Schtick
Reply to  Steve Case
July 7, 2020 9:16 am

Earlier in the pandemic, I listened to a doctor explain (can’t remember who or where sorry), that they could not find a single lupus patient who had contracted COVID-19. He had put out an appeal to try to find one out of the 2 million or so lupus patients in the US who had the virus.

Grumpy Bill
Reply to  Steve Case
July 7, 2020 9:40 am

It’ inexplicable why such data hasn’t been collected and collated. It’s very likely easily available.
I am currently doing my own study where n=1=myself.

A C Osborn
Reply to  Steve Case
July 7, 2020 10:51 am

You mean that you have not seen the Italian retrospective survey?

https://www.jpost.com/health-science/italian-scientist-says-she-discovered-main-mechanism-behind-covid-19-626737

You have to read quite a long way down to find it 65,000 patients, only 20 with covid-19.

Scissor
Reply to  A C Osborn
July 7, 2020 1:22 pm

That seems to be significant.

Nicholas McGinley
Reply to  Steve Case
July 7, 2020 12:24 pm

I posted about this last night.
People with lupus are getting it, in high numbers.
And when they do, it is bad.
Here is a link to one of the posts I made.
And here is the link to a regirstry of 600 patients with rheumatic disease who are infected.
45% wound up hospitalized, so far, and 9% are dead…so far.
There was no protective effect from being on HCQ when they got sick.
There were two groups that had a protective effect…those taking biologics, as they are called.

Anti-TNF drugs worked the best, they were protected, but only partially.
People taking anti-IL-6 drugs were also protected, but not as much.

Here is the link, and this is what good data collection looks like:
https://ard.bmj.com/content/annrheumdis/79/7/859.full.pdf

mario lento
Reply to  Nicholas McGinley
July 7, 2020 12:39 pm

You can’t make the statement there is no protective effect. What was the state of their health… Lupus is an auto-immune disease… whereby treatment quells the misguided immune system.

If you understood how HCQ and Zn worked you would know that is slows viral replication in the presence of ample Zn, which gives your “functioning” immune system time to respond.

Two parts, get it?

If you cared about providing information, why do you treat every issues like a biased hack?

Nicholas McGinley
Reply to  mario lento
July 8, 2020 9:11 am

I did not originate the statement.
I was summarizing one of the results of the work I linked to.
It is right in the first paragraph of the paper.

Here is the text:
“Results A total of 600 cases from 40 countries were
included. Nearly half of the cases were hospitalised
(277, 46%) and 55 (9%) died. In multivariableadjusted models, prednisone dose ≥10mg/day was
associated with higher odds of hospitalisation (OR
2.05, 95% CI 1.06 to 3.96). Use of conventional
disease-modifying antirheumatic drug (DMARD)
alone or in combination with biologics/Janus Kinase
inhibitors was not associated with hospitalisation
(OR 1.23, 95% CI 0.70 to 2.17 and OR 0.74, 95% CI
0.37 to 1.46, respectively). Non-steroidal antiinflammatory drug (NSAID) use was not associated
with hospitalisation status (OR 0.64, 95% CI 0.39 to
1.06). Tumour necrosis factor inhibitor (anti-TNF) use
was associated with a reduced odds of hospitalisation
(OR 0.40, 95% CI 0.19 to 0.81), while no association
with antimalarial use (OR 0.94, 95% CI 0.57 to 1.57)
was observed.”

The information that is the basis of that summary is extensively documented ands described in numerous tables of data.
That is what the data says.
It is not what I say, and your assertion that ” I cannot say it” is nonsense.

paul courtney
Reply to  mario lento
July 8, 2020 12:45 pm

mario: I urge you to reconsider this. McGinley’s only agenda is to live up to the creed, “first, do no harm.” He has been ultra cautious re: hcq, but he explains himself and cites his sources. You seem like a reasonable guy, read his posts and tell me where he is wrong. He demonstrated a clear understanding of how the “two parts” work in a lab. He hasn’t seen good evidence (he doesn’t make Mr. Stokes’ error of re-defining “evidence” to suit a whim) that it works in the field.
P.S.- Not that he needs me to step in, one thing you must grant is that McGinley stands his ground. In any event, he doesn’t deserve to be insulted.

mario lento
Reply to  paul courtney
July 8, 2020 1:07 pm

Hi Paul: Thank you for your ability to craft a gentle missive.

If you are responding to my statement, “You can’t make the statement there is no protective effect.”
I could restate it as, “You can make any statement you want.” Not that I am the decider of who should have opinions. 🙂

There is no “proof” that HCQ and Zn at the prescribed levels and duration we are talking about causes widespread harm or does not have a protective effect. One can argue about that all day long, so that will not be resolved by this response.

There is plenty of “evidence” that HCQ and Zn have a protective effect.
One can argue about whether or not HCQ is defined as an ionophore or not all day long. I have only seen evidence that it is called an ionophore by doctors in the field. It is not clearly defined how it can be determined, hence the debate.

The evidence that there has been a protective effect has been shown in many cases.

The debunking of the dangers of HCQ for Covid patients has also been widely circulated. The debate will go on and not be settled here.

So it goes back to “First do no harm”, the Hippocratic oath. I am glad you brought this up.

That does not mean, do nothing! I think there is strong evidence that in this case, there is much more harm being done, by not using HCQ and Zn early on, as prescribed.

Look at it as a probability. Doing nothing… you get what we have. Supplying HCQ and Zn early on has shown no harm, and has shown better outcomes fewer deaths.

Nicholas McGinley
Reply to  paul courtney
July 8, 2020 5:59 pm

These are the people that have been much discussed…people with diseases like RA and lupus, and other conditions of a similar nature called rheumatic disease, collectively.
The status of this group of people has been much talked about, and it is now obvious most of the talk has been based on erroneous information.
In other words, people are saying a lot of stuff that is not true about people who have been taking HCQ, and using the misinformation to invent a bunch more misinformation.
So, no w there are multiple data sets of these specific individuals.
Interestingly, many people with such diseases take some of the other types of drugs that are being used to treat covid patients.
And a sample of 600 people with these conditions, of which lupus appears to be the second most common, and who have also contracted COVID-19, has been closely examined and a whole bunch of information about their condition and situation is compiled.
This is not based on what anyone wants to think, or believes to be the case, or was hoping would be found to be the case, or anything like that.
This data is all gathered based on actual people and what they took and how they have fared after contracting COVID 19.
Some might view it as extremely valuable information from which a wealth of insight might be gleaned.
Of course, that would be people who would like to have factual information, no matter what it tells us.
The type of person who is of a scientific bent is one example of who might want to get data of a factual and unbiased nature.
Others might seek to dismiss it, and give it no weight, or make excuses for why it is not important, or relevant, even if such efforts were transparently biased.
I am not at all sure what would motivate anyone to do so, but here we are.

So, these people are already taking this stuff.
IL-6 blockers.
HCQ.
Anti-TNF drugs.
Steroids.
And there is what happens to these people, compiled in detail.
Summarized and analyzed.

Anyone can see that we have people in this country who have appointed themselves professional obfuscators.
Exactly why will be a question for the ages.

Nicholas McGinley
Reply to  paul courtney
July 9, 2020 4:50 am

Thank you Paul.
I really do appreciate someone who defends the person getting ganged up on.
As Rud has aptly put it, I am interested in popularity contests.
We have people with whom I have had little to agree with over many years on this site, with whom I am now in almost full agreement on at some aspects of what is happening with this pandemic.
I have no problem or qualms about standing up next to these people and supporting them on that which we can agree on.

Nicholas McGinley
Reply to  paul courtney
July 9, 2020 4:51 am

Crap…NOT interested in popularity contests.

Editor
Reply to  Nicholas McGinley
July 8, 2020 11:22 pm

There’s a very significant difference between the Italian study as posted by A C Osborn, and the BMJ article Nicholas McGinley posted. The italian study reported that very few of the patients taking HCQ were diagnosed with WuFlu. The BMJ article looked only at patients that had already been diagnosed with WuFlu.

Reply to  Mike Jonas
July 9, 2020 12:56 am

“The italian study reported that very few of the patients taking HCQ were diagnosed with WuFlu.”
It was not a study, but a nonsense newspaper report
From Science:
“The number is completely fictional. As mentioned here in the comments, the president of the Italian Rheumatology Society was contacted directly and states that this number is completely wrong, that the society is monitoring 150 patients in its registry, 20 of whom are taking hydroxychloroquine. The 65,000 number is bogus.”

Nicholas McGinley
Reply to  Mike Jonas
July 9, 2020 7:16 am

Mike,
You are correct.
I have no confidence in the Italian study, since it has been refuted by people within the community of people represented.
I am going to stick to opining on information that stands up to scrutiny as being legitimate.
I am not saying the Italian study is accurate or has any value or not.
What it appears to be is an estimate of the number of people with the disease, vs the number that have been heard from that report taking HCQ and then getting Covid.
But it is very obvious that most people who have these conditions have not volunteered their information.
It is unclear why anyone would consider this a useful way to determine infection rates.

I agree with you when say there is a difference between what is being compiled.
The BMJ study is very clear on how the data is sourced.
After a call went out for patients to enroll in a worldwide registry, those who responded were contacted through their doctors, who supplied the information that was compiled.
So they are not trying to make any observations of overall infection rates.
What they are doing is looking at the set of people that have enrolled in the registry, which was voluntary.
They then separated out all of these individuals who had contracted COVID-19.
It was not limited to lupus patients.
It was limited to all people with what is classified as a rheumatic disease.
This is a group of diseases with certain aspects in common, and for whom the same types of medications are often found to relieve symptoms.
They are regarded as incurable and lifelong conditions, often progressive, sometimes severe, sometimes mild. Typically with recurrent flare ups and then remission periods of more mild symptoms.
These diseases are disorders of the immune system.
Some have called them autoimmune diseases in the past.
But the understanding and the description of the etiology has evolved and become more refined over time.
That phrase is not as commonly applied any more.
In any case, there was for some reason a focus on lupus patients in the online scuttlebutt regarding these people.
I think we should look at the whole set of these patients and not focus on one subset of them.
Because what was germane to the topic at hand was that we have a population who have been on long term courses of the medications we now need to know more about.

In other words, there is not any obvious rationale to only consider lupus patients, and not all people who were already taking these drugs when they got COVID.

In any case, whether we look at them all, or just the lupus patients, we have individuals who were on HCQ, and others who were not.
Some of them were taking these other drugs.

Since what we are concerned about is COVID and what helps and what may help and what is not being shown to help, we should look at everyone in the set of patients, and later we can decide who and what medications are relevant.

Cast a wide net, and then sort the information.

So this comparison in the BMJ report is not answering the question of “How many lupus patients got COVID?”
It is looking carefully at people who took one or more of these group of medications, and other people who did not take any of them but who had the same underlying conditions.

We can now compare lupus patients who took a malaria drug and then got Covid, to lupus patients who did not take a malaria drug and then got Covid, and examine the data for similarities or differences in how they fared upon getting the disease.

It seems logical that this methodology has a good chance of eliminating self reporting biases.

We do not need to know how many people have these conditions all over world, what the underlying rates of disease was in those places, etc. That gets cumbersome and impossible to parse right out of the gate.
For one thing, people with these diseases, particularly lupus, are known to be very careful about avoiding sick people…they are very susceptible to infectious diseases because they are on immunomodulating drugs.
i.e., they take drugs that shut down part of the immune system.
When they get sick, it is often very much worse for them than a healthy person.

Bob boder
July 7, 2020 7:06 am

Which one of the usual suspects who defend science consensus will say this study doesn’t mean anything?

Robert of Ottawa
Reply to  Bob boder
July 7, 2020 11:35 am

Yes there does seem to be a divergence of opinion on several areas of scientific doubt where the consensus follows the government money which follows the establishment opinion. Epicycles anyone?

Henry Pool
July 7, 2020 7:09 am

Goldstein, did you know that a survey of climate scientists proves nothing about the climate?

icisil
Reply to  Henry Pool
July 7, 2020 7:36 am

Climate scientists live in a virtual world playing with numbers. Doctors actually heal people. Real world results are hard to argue with, but you’ll try.

Henry Pool
Reply to  icisil
July 7, 2020 8:17 am

Polls and surveys said Clinton would win in 2016.

Clyde Spencer
Reply to  icisil
July 7, 2020 2:44 pm

icisil
Get real! Results have to be turned into numbers that are impacted by confounding factors such as demographics. The only way you get around that is by stating “I know a doctor who claims he has cured people.”

mario lento
Reply to  Clyde Spencer
July 7, 2020 3:01 pm

I wrote a post earlier… you’re talking past each other.

Yes, numbers are great. But when no one will do a true double blind placebo based study (and it’s been months now) due to politics… and while the studies that have been done use bad data… or use the drug in a way it is KNOWN not to be effective, we are left to use our common sense.

That is, it appears that taking a safe drug at a low dose has nearly zero downside risk and is shown to dramatically reduce effects of the virus.

Meanwhile, people are dying and we are arguing past each other.

icisil
Reply to  Clyde Spencer
July 7, 2020 4:38 pm

CS, the only thing that matters is that people don’t progress to serious illness. How do you rationalize the Texas doctor treating his infected nursing home patients with HCQ, and the vast majority did not get seriously ill or die? That is a highly unusual occurrence in that context, or demographic. To say that is meaningless is meaningless.

Dave Fair
Reply to  icisil
July 7, 2020 4:53 pm

And is indicative of Clyde’s manevalent ideology, icisil.

Nicholas McGinley
Reply to  Clyde Spencer
July 10, 2020 11:10 am

Clyde,
Oh, yeah?
Well, my niece’s teacher’s cousin’s step father heard that there was a person who once knew a doctor who said he never heard of that happening.

Dodgy Geezer
July 7, 2020 7:11 am

This confuses me. if there are lots of doctors who consider HCQ as being an appropriate treatment, why is the literature FULL of studies showing it to be of either no value, or positively harmful?

if the answer is that politics is driving these findings rather than dispassionate science, then I am all adrift – because I cannot then believe ANY published finding – either supporting or refuting this drug….

Krishna Gans
Reply to  Dodgy Geezer
July 7, 2020 7:23 am

Look at the protocols of the different studies, you see why there are diffetent outcomes.
Late use versus early use, as so often discussed here, but my impression is, shortage in remembership seems to be mainstream here.

icisil
Reply to  Dodgy Geezer
July 7, 2020 7:26 am

Why would you listen to anyone or anything that is not actually healing patients? If doctors say HCQ is helping their patients, why would you not at a minimum consider what they say is true?

Dodgy Geezer
Reply to  icisil
July 7, 2020 10:03 am

Because I have been lied to frequently before. And the result of being lied to by authoritative figures is to make me suspicious of ALL authoritative figures – not just the ones I disagree with…

icisil
Reply to  Dodgy Geezer
July 7, 2020 10:58 am

Yah, but not everyone’s a liar. The flux lines of this epistemological exercise tell me that many independent, highly skilled practitioners are reporting a benefit from personal experience, whereas many establishment voices with conflicting interests are trying to find fault without anything but the usual framing and manipulation of data. What does each have to gain and/or lose?

icisil
Reply to  icisil
July 7, 2020 12:50 pm

Speaking of conflict of interests

New Docs: NIH Owns Half of Moderna Vaccine
https://childrenshealthdefense.org/news/new-docs-nih-owns-half-of-moderna-vaccine/?itm_term=home

John VC
Reply to  icisil
July 8, 2020 8:04 am

Probably late to the game, but read this article about the Gilead/Boston hospital test on Remdesivir / the Lancit report on HCQ, and the complicity of the CDC.

https://www.lewrockwell.com/2020/07/no_author/lancetgate-scientific-corona-lies-and-big-pharma-corruption-hydroxychloroquine-versus-gileads-remdesivir/

personally, I think it boils down to free choice–if I want the Remdesiver and can pay the price, the doc should provide it. Same with the HCQ+ zinc. My body, my choice…

Nicholas McGinley
Reply to  Dodgy Geezer
July 7, 2020 7:31 am

This is a poll dated April…early April.
Worthless.
Who cares what people thought back then?
Get current opinions from the same people and see how it has changed.
Besides, the people that matter are not a survey of random doctors, but the ones that work with patients in critical care situations.
Back around then my very busy doctor told me he had yet to get back a single positive test result.

icisil
Reply to  Nicholas McGinley
July 7, 2020 7:48 am

You have it backwards. The ones to listen to are the ones who can keep patients from progressing to critical care. I think the general consensus is that HCQ doesn’t do well for critical care patients, so why would we listen to critical care specialists about HCQ?

John VC
Reply to  Dodgy Geezer
July 7, 2020 7:53 am

Follow the money Geezer. Treatment cost of HCQ–about 7 dollars. Treatment cost with Gilead’s remdsiver (sp?) about 2400 dollars. Ask about the financial ties to Gilead certain CDC officials have among others.

Henry Pool
Reply to  John VC
July 7, 2020 8:13 am

Rolling a patient on their side (prone position) is an effective treatment for low blood oxygen. How much does that cost?

Derg
Reply to  Henry Pool
July 7, 2020 9:25 am

I would prefer to be treated before I need to be rolled 😉

sycomputing
Reply to  Derg
July 7, 2020 10:56 am

Lucky you. Every time I need to be treated I get rolled ($$$$$)

Loydo
Reply to  Derg
July 7, 2020 2:21 pm

So thats how its done…

Dave Fair
Reply to  Loydo
July 7, 2020 2:22 pm

Wit is not your strong suit, Loydo.

sycomputing
Reply to  Derg
July 7, 2020 10:20 pm

So thats how its done…

“Ba-dum-tsss,” yes, sarcasm, no.

https://www.youtube.com/watch?v=6zXDo4dL7SU

xoxo

David Bufalo
Reply to  John VC
July 7, 2020 8:34 am

My opinion, exactly.

Dodgy Geezer
Reply to  John VC
July 7, 2020 10:12 am

“Follow the money Geezer…”

Oh, that certainly makes me suspicious of Remdesivir. But it tells me nothing about the efficacy of HCQ. And the more people offer that kind of argument, the more suspicious I get about ALL the trials…

I think that, as a society, we have successfully undermined Science. I suspect that social media has had a large part to play in this – allowing the worst tribal instincts of humanity free play….

icisil
Reply to  Dodgy Geezer
July 7, 2020 11:25 am

Good doctors are not scientists; they are healers. Beware the doctors who are only scientists.

Nicholas McGinley
Reply to  Dodgy Geezer
July 7, 2020 8:04 pm

He is flat out lying about the price of remdesivir.
It has been established that 5 days is as good as 10 days.
1 vial will cost $320.
But no one has bought any yet.
Gilead gave away the entire supply in existence, and since it takes 6 months to make a single dose, they are not yet in possession of any to sell.
But, it will be ready soon.
Trump has secured the entire supply for the US government, through to September production.
By December they think they will have made enough for a couple million people.
It saves 5 days off of an average hospital stay.
That translates into a $12,000+ savings per patient.
Every jackass who refuses to get it will cost us all a big fat pile of cash.
Meanwhile, hundreds of clinical trials are ongoing, in every country, and every state, and almost every large and medium size city. Meaning it is free.
Trials for other drugs vs standard of care will now mean other drug vs remdesivir.
IOW…no one will get placebo anymore in any trial.
It would be unethical.
SoC is remdesivir.
I seem to recall everyone is supposed to have insurance.
And also that the government has said no one is gonna get charged for any treatment related to getting COVID.
Did that get rescinded?

Go to any business news site and enter remdesivir in a search, and this info will be there.
Except the clinical trial parts…go to clinicaltrials.gov for that info.
Any day now, Gilead will begin clinical trials for an at home inhaled version of remdesivir.
Anyone who thinks they have the virus can get it for free in any one of many clinical trials, or another usage called expanded access…all free.
In fact, clinical trials pay participants for their time.
Many of the trials are giving remdesivir and another drug.
I would enroll in remdesivir plus the anti-IL6 drug trial, if I had it.

Here is a link set up to go directly to the 40 trials with remdesivir.
They added one since yesterday.
Number 11 on the list is remdesivir plus Tocilizumab (anti-IL6 monoclonal antibody)

But what do I know, I am just a moron troll.

Nicholas McGinley
Reply to  Nicholas McGinley
July 7, 2020 8:30 pm
SteveT
Reply to  Nicholas McGinley
July 9, 2020 11:54 am

How can Remdesivir be the “standard of care” when it is virtually brand new and nobody knows what side effects may be waiting. There have been no proper trials over any time period of about 6-8 months as it was only rushed out of development last year. (that is my understanding, sorry if anyone can correct me).
The main claim for remdesivir seems to be as you said – reducing hospital stays by about 5 days. Knowing it is usually used for more serious cases, does this mean that patients die sooner? Statistics can be used in many ways!

One can stand up and say trial this, trial that, studies show etc. but this is a situation where people are dying in significant numbers and many within two or three weeks of realising they are ill.
In this situation I am for going early with what are impressive results with HCQ and Zinc sulphate and including azythromycin if there is indication that pneumonia infection is present (although it may be late in the day for best results in that case). Obviously under a doctor who can check for possible heart contraindications.

The pushing of remdesivir, given the complete lack of long term safety and underperformance v. HCQ etc seems highly irrational.

The cost comparison also raises concerns of propriety in my mind.

SteveT

Michael Jankowski
Reply to  John VC
July 7, 2020 11:18 am

The notion that “big pharma” would let much of its current and future customer bases die-off on the odd chance that one of them would come out a with a new COVID-19 treatment is not following the money. They’ve lost lots of seniors and future seniors with 3-4 scripts. Remdesivir is a $1B development. They’ll make that back by the end of Sept if things go ideally-well. If not, then the future of the drug is uncertain. And everyone else besides Gilead was a loser in wasting research money but not hitting it big.

Neo
Reply to  Dodgy Geezer
July 7, 2020 12:09 pm

One of the most disgusting aspects of the COVID pandemic has been the ruthless jockeying by drug companies and their agents to push their own drugs and actively bad mouth possible competitors without regard for the good of the public.

Clyde Spencer
Reply to  Dodgy Geezer
July 7, 2020 3:07 pm

Dodgy
You asked, “… why is the literature FULL of studies showing it to be of either no value, or positively harmful?” It is the same reason that about half of peer-reviewed, published studies can’t be replicated in the medical field. That is why large samples of random subjects have to be used, and confounding factors such as co-morbidities have to be accounted for. Early results from ad hoc clinical trials, with a disease that a large proportion of those infected have mild to no symptoms, used only in the early stages, should be expected to have good results. That is why so many different drugs appear to have some efficacy. What is even more critical is that those not in need of hospitalization, or just some palliative care for a few days, are not the important ones. It is those, for whom HCQ is not recommended, that are most in need of effective treatment. At this point in time I wouldn’t give much credence to any of these early ‘studies.’ It is understandable that a physician who can monitor his/her family members would, out of desperation because of the lack of alternatives, consider prescribing HCQ if a family member showed signs of possible COVID-19. If they get well, it might have been HCQ or it might have been an inherent resistance to the virus. It is like the drunk blowing a whistle to keep the pink elephants away. The real test is if people who are seriously ill can be cured. Anything less is Witch Doctor medicine.

Dave Fair
Reply to  Clyde Spencer
July 7, 2020 4:30 pm

BS, Clyde. The severely ill are dying at prodigious rates NOW, no matter the treatment! The real test is to find out how to keep people from becoming severely ill. Your ideological stance is ugly. F**k off.

Dave Fair
Reply to  Clyde Spencer
July 7, 2020 4:32 pm

P.S., Clyde. With my recent diagnosis of WuFlu, this is personal now. So, again, F**k off, Troll.

William Astley
Reply to  Dodgy Geezer
July 8, 2020 2:49 pm

In reply to ‘Dodgy Geezer’:

Dodgy, look at motive. Who win and Who would lose to hide a very effective Covid treatment from the American people?

If people are lying, trying to hide a very effect Covid treatment, that is criminal/an attack on the US people and the lying needs to be called out. Particularly as this appears to be organized lying.

Six US Michigan Hospitals, financed by the Henry Ford foundation are not going to lie about the fact that 2541 patients….

….Treated with HCQ/AZ plus zinc within 48 hours of admittance to the hospital …

(that is not early treatment, that is earlish treatment, a doctor in New York treated 500 of his patients as soon as Covid symptoms were detected, his results is a reduction in the covid death rate by a factor more than 10.)

….were 71% less likely to die of Covid, as compared to the patients that did not get the treatment. Interesting there was not a single heart attack in the treated group, while one Fake HCQ study alleged that 25% of those treated with Covid died of heart attack and there was a reduction in outcomes for the HCQ treated patients.

Dodgy Geezer, science stops working when organized paid groups of people have agendas and lie and take over the media. This is different than a single incorrect study.

We do know that the Lancet study that lied and that presented false data has been withdrawn….

We also know that company that supplied the data for that study has refused to supply source data and is not returning phone calls.

Science also works because there is only one correct answer. A group of doctors in Michigan are not going to lie about the effectiveness of HCQ. There going to do what they are told and they are going report unfiltered results.

Six different hospitals, Michigan hospitals treated 2541 patients and their evidence based results are….

Early treatment of Covid patients (the earlier the better) with Hydroxychloroquine and Azithromycin plus zinc reduced the covid death rate as compared to untreated patients by a 71%.

https://www.ijidonline.com/article/S1201-9712(20)30534-8/fulltext

Treatment with Hydroxychloroquine, Azithromycin, and Combination in Patients Hospitalized with COVID-19

Results
Of 2,541 patients, with a median total hospitalization time of 6 days (IQR: 4-10 days), median age was 64 years (IQR:53-76 years), 51% male, 56% African American, with median time to follow-up of 28.5 days (IQR:3-53).

Nicholas McGinley
July 7, 2020 7:17 am

April?
It is now July.
Might as well look at polling data to help decide about an election.

In the world of climate skepticism, we regard people who try to reason by citing surveys as the most unscientifically minded people in the arena.
This is no different.
Data from polling two months ago has zero weight, and can even be taken as obviously biased, towards when less was known.
Look at how the Henry Ford Health System data was skewed by a sequential survey of patients.

Krishna Gans
Reply to  Nicholas McGinley
July 7, 2020 7:32 am

Indeed July, but 2020, not 1520 😀

icisil
Reply to  Nicholas McGinley
July 7, 2020 7:42 am

It’s a world of difference. One is an abstraction that has nothing governing interpretation; the other is the personal appraisal of highly skilled professionals.

Gums
Reply to  Nicholas McGinley
July 7, 2020 8:05 am

Salute!

c’mon, NickMc…..

I do not recall the cosmic “peer(brotherin law) reviewed, double blind, clinical trial that resulted in the FDA to recant on emergency use of the malarial drugs.

All we got to use is testimony from many practitioning doctors and what they did and what seemed to work.

Wanna do a serious study of HCL and its “helpers”?

How can we round up few thousand folks of all races and colors and blood types and underlying medical conditions and then expose them all to the bug in very controlled environmental conditions and then separate the infected from those that did not seem to suffer? Then we examine all kindsa things for both groups, but we start a HCL+ regimen on the infected ones. Then we look at those poor souls for blood type, race, underlying conditions, etc as we watch them die or recover. And how many had heart rhythm problems or whatever that can be traced to the HCL? Guess we should have also taken another thousand off the street with no Corona problem and had them take the HCL like I did not of my own free will years ago. How many of them died or had debilitating problems compared to Advil or the myriad of drugs advertised on TV for problems most people might have and didn’t have the problem from the guy in front coughing?

My not so humble opinion is the FDA caved to the deep state and ignorant, politically motivated mass media.

As with thousands of ads on TV, all the FDA had to do was include that famous line at the bottom of the screen warning about side effects that may occur in a very tiny of people, and relate that to the veteran numbers of we millions that ingested the damned HCL for years and croaked.

Gums rants….

Krishna Gans
Reply to  Gums
July 7, 2020 8:33 am

We should read HCL as HCQ, because HCL is somewhat differnt, isn’t it ? 😀

Nicholas McGinley
Reply to  Gums
July 7, 2020 11:26 am

I have no idea what you are trying to say Gums.
What I am saying is very clear: April was three months ago.
Since then a lot of new information has come to light.
Since then many more people have been treated.
Those polls are still being done, so why not report the up to date ones?

Who wants to guess what they say?
I already checked.

Gums
Reply to  Nicholas McGinley
July 7, 2020 4:04 pm

Salute!

No problem, NickMc

I am trying to make the point that there has been no super duper study or trial that makes taking the malaria prophylactic some kinda death sentence.

The malaria compounds have been used and studied for eons.

As with all the new, magic drugs advertised on every TV channel three times and hour, its warning would be that only 1 person in 100,000 might have indigestion, and anyone with an existing heart problem and high blood pressure should consult their doctor ( do not know how you got the HCL without seeing your doctor, but gotta put that in the add to mitigate lawsuits).

That is my point Nick.

The damned malaria stuff seems about like Advil, and should be treated the same.

If the stuff helps, then great, but the FDA and certain media should not discourage its use as long as the warning we find on every label states that the efficacy has not been proven to CURE covid-19 and that no other compound has been proven to cure the virus attacks upon your body.

There is a lotta difference between asserting some chemical or drug will CURE a disease versus suggesting a possible use of an existing compound that has been thru the rigorous testing to get approval by the FDA for widespread use without special scrutiny.

I do not find an assertion that HCL plus other stuff could cure the corona virus attack. All I can find is that it MAY reduce the severity or shorten the problem.

back to the bbq, as the damned critters can not fly and don’t smoke or heat or breeze.

Gums sends…

Dave Fair
Reply to  Gums
July 7, 2020 4:41 pm

Gums, please ‘send’ your location; I’m hungry.

Ron
Reply to  Gums
July 8, 2020 6:51 am

Wanna do a serious study of HCL and its “helpers”?

There are still more than 100 studies enlisted for HCQ in the U.S alone at the moment, other countries are doing trials as well, so I guess at some point we will have sufficient data for one or the other outcome.

Disclaimer: I would really like to see a comparison Zn alone/HCQ alone/HCQ+Zn.

J Mac
Reply to  Nicholas McGinley
July 7, 2020 11:40 am

RE: “Look at how the Henry Ford Health System data was skewed by a sequential survey of patients.”

Please provide evidence for your allegation. Weren’t you the one dismissing Leo’s submission and touting a ‘sequential’ survey of doctors opinions. Memory refresher: “Get current opinions from the same people and see how it has changed.” D’OH!
Do as I say, not as I skew?

Dave Fair
Reply to  Nicholas McGinley
July 7, 2020 4:34 pm

Your concern about the upcoming election is noted, St. Nicholas.

Bruce Cobb
July 7, 2020 7:21 am

Unfortunately, doctors can be extremely close-minded, especially with anything that might go against their training, and anything smacking even remotely along the lines of preventive and/or natural or non-pharmaceutical. I realize a lot of that is to protect themselves from lawsuits, but it means that it can be difficult to accept what they say at face value.

Bob boder
July 7, 2020 7:24 am

Bingo and the winner is McGinley!
I should have put money on it.

Krishna Gans
Reply to  Bob boder
July 7, 2020 10:59 am

I didn’t even question that, clear as clear water is who will be the winner 😀

Bob boder
Reply to  Krishna Gans
July 7, 2020 11:13 am

Yeah, I am pretty sure he’s one of are old time frauds, Brandon Gates, Griff, Tony Mcleod or one of the other name changing frauds, the writing style is familiar i just haven’t put my finger on it yet but I will.

Clyde Spencer
Reply to  Bob boder
July 7, 2020 3:13 pm

boder
I don’t see the similarity in the writing styles. Ask Anthony if they are the same people.

Nicholas McGinley
Reply to  Bob boder
July 7, 2020 8:17 pm

I am pretty sure you are a jackass, Boder.
Gates does not come round here no more.
Last time he was here was the time I argued him straight into a tonic-clonic seizure.
I am not sure when that was…
After this time I pantsed him and stole his lunch money:

https://wattsupwiththat.com/2015/04/26/inquiry-launched-into-global-temperature-data-integrity/

Last time I saw Tony, was that time he lost a $1000 bet with me, that every one here witnesses, regarding his inane opinion on Arctic sea ice.
How do I know you are not him? He was nearly as unpleasant as you, so I am suspicious…

Do not think I am forgetting about that money, Tony!

sycomputing
Reply to  Bob boder
July 7, 2020 8:44 pm

the writing style is familiar i just haven’t put my finger on it yet

Alright, you caught me. It is I and he is me.

It was fun while it lasted . . . 🙁

Nicholas McGinley
Reply to  sycomputing
July 7, 2020 10:16 pm

Speaking for myself, I am way too quick and nimble for him to ever gets his greasy fingers in me.
I have to take a shower.

littlepeaks
July 7, 2020 8:20 am

OT — when I get a severe illness, I have a symptom that hasn’t been discussed — severe whining (at least that’s what my daughter says). Will hydroxychloroquine control that symptom?

BTW, I had a dental appt. scheduled for this afternoon, and I got a call from the dental office saying they cancelled it because my dentist wasn’t feeling well. I asked about covid-19, and the staff told me they don’t know — he’s going to be tested for it — and this is the second time he’s been tested. Earlier this year, one of his dental hygienists quit, because she was paranoid about catching covid-19. We talk a lot because my family has been going there for over 30 years. And dental problems is one of my major malfunctions, and I help them stay in business.

George V
July 7, 2020 8:31 am

Here’s a HCQ study published a few days ago, for what it’s worth, conducted by a Detroit area hospital system. Death rates between HCQ treated vs. non-treated patients. HCQ cut death rates . Their results indicate early treatment is needed for effectiveness.
https://www.henryford.com/news/2020/07/hydro-treatment-study

Dave Fair
Reply to  George V
July 7, 2020 1:36 pm

+42^42. Old military saying: When in doubt, whip it out. The HCQ+, that is. Was diagnosed with the ChiCom virus’ WuFlu yesterday evening after developing symptoms a few days ago. Will be contacting my primary care Dr. this afternoon. Will certainly demand HCQ+ treatment. Will go outside the VA if necessary. F**k St. Nicholas.

BTW, it was in fighting the Asian Marxists that I got my combat wounds, which wound up prepaying my healthcare. What goes around.

Never deal with societies that follow Marxism, eat weird wild animals, live in close proximity to pigs and ducks and unhygienically slaughter animals in inner cities. Whatever the costs, limit Chinese travel, move manufacturing of most things back to the USA and destroy the ChiCom monster economically as well as militarily.

mario lento
Reply to  Dave Fair
July 7, 2020 1:41 pm

God bless you for your service:
I will hope the your last sentiment is never to be needed, having to use our military, except as a show of strength by being strong… Get well fast and let us know how you are doing with treatment.

Our Nicholas comes more than once a year, unfortunately.

Dave Fair
Reply to  mario lento
July 7, 2020 2:04 pm

Not suggesting attacking the ChiComs, just containing.

mario lento
Reply to  Dave Fair
July 7, 2020 2:24 pm

That’s a great clarification… Your posts are inspirational…

Dave Fair
Reply to  mario lento
July 7, 2020 3:12 pm

Thank you for your sentiment, Mario. I’ve been called many things when dealing with numerous controversial business and political issues over the decades, but inspirational is a new one! When opposing popular (but bad) ideas, the most common description was antisocial asshole.

Sadly, the Woke brigades don’t want to listen to reasoned experience. It will take at least another generation for the inexperienced (and those who won’t read history or who actually misinterpret history) to make enough mistakes to learn the lessons of history and the bad outcomes of good intentions. Humans are not perfectable; centralizing power to force perceived (usually political or religious) perfection always turns out badly. Democratic free markets usually shake out the bad ideas; not perfectly, but better than anything else.

Ideological movements always eat their own. The currently pervasive cancel culture, made more toxic by technology, is now dragging down its own idols of old. It will continue to drive society into waring camps and it will not end well for the common man. E Pluribus Unum, the motto of the US, is the great idea of American democracy. Tearing it down will destroy us.

mario lento
Reply to  Dave Fair
July 7, 2020 3:24 pm

Amen that Dave. I learned later in life why I was usually the one taking a counter view to many arguments… and that realization was eye opening to me. You speak cogently, and sound fortified with experience when you counter in an argument. It shows.

Old.George
July 7, 2020 8:44 am

Since HCQ is a prescription drug let’s look at OTC.
IF one of the reasons HCQ works is because it is a zinc-ionophore allowing zinc to go inside the cells from the bloodstream, there are a number of OTC products which are zinc-ionophores. The one I take, along with a Zn supplement, is Quercetin.

John VC
Reply to  Old.George
July 7, 2020 9:29 am

I’ve been doing the same. Quercetin is found in red apples and other food stuff. I’ve been eating an apple for breakfast for years now–apple a day keeps the dr away. I read about the need for zinc in a healthy immune system back in Feb. and started that supplement then, along with upping my Vit.C &D. added the quercetin supplement just recently as I figured the amount in a single apple wasn’t all that much, and what the hey–doesn’t cost very much, and assume that the VA won’t be prescribing HCQ as a preventative anytime soon.
Never get a flu shot, don’t use anything that brags on killing 99.9% of germs, and the only issue I have is some mild seasonal allergies. Got all the health conditions associated with my age (74), but never get sick, and intend to keep it that way with a strong and healthy immune system –not vaccinations.

Reply to  John VC
July 7, 2020 10:14 am

John, the Dutch have a saying:
A herring a day keeps the doctor away. Two herrings a day keeps everyone away.

bonbon
Reply to  Ron Clutz
July 7, 2020 12:06 pm

And the Finns – a 20-year fermented herring empties the entire block, pronto.

Still, I wonder if anyone has checked the vitamin content of fermented herrings. I’ll bet we are in for a surprise!

don rady
Reply to  John VC
July 7, 2020 2:27 pm

Elderberry is highly effective against human coronavirus NL63, one of the three known
coronaviruses to enter cells through the ACE2 “back door.” It directly stops the attachment of
the virus to ACE2, so probably does the same for the new coronavirus as well. Since viruses
need to hijack our cells in order to multiply and spread, and since if they don’t do that they
eventually die, blocking the entry of the virus into the cell destroys its ability to multiply, spread,
and survive.
Elderberry’s effects aren’t limited to blocking the ACE2 back door. It also destroys the lipid
envelope of avian infectious bronchitis virus, a coronavirus that infects chickens and other birds,
and in humans it is effective against the flu, which isn’t a coronavirus at all. None of these
viruses enter cells using ACE2. Still, its ability to directly block the use of ACE2 as an entryway
means it has the potential to nip the new coronavirus in the bud and prevent it from ever
establishing an infection in the first place. As a result, it deserves a place as a preventative and
first line of defense against the new coronavirus.

Dave Fair
Reply to  don rady
July 7, 2020 3:22 pm

And your mother’s breath smells of Elderberry wine! An old bad joke, Don.

William Astley
Reply to  don rady
July 8, 2020 3:00 pm

Hi ‘don rady’,

Hey Don, please do not make stuff up. Elderberry is not highly effective against Covid.

Regardless of sex or age, Vitamin D normal people, blood serum 25(OH)D levels less than 20 ng/ml are 19 times more likely to die from covid than vitamin D deficient people 25(OH)D blood serum levels less than 30 ng/ml.

Researchers know that because they measured the 25(OH)D levels in the blood.

4000 UI/day per person is required to raise the US populations 25(OH)D levels above 30 ng/ml.

82% of the US black population, 69% of the US Hispanic, and 42% of the US general population is Vitamin D deficient.

Prevalence and correlates of vitamin D deficiency in US adults.
https://tahomaclinic.com/Private/Articles4/WellMan/Forrest%202011%20-%20Prevalence%20and%20correlates%20of%20vitamin%20D%20deficiency%20in%20US%20adults.pdf

4000 UI/day of Vitamin D supplements is required to raise the serum 25(OH)D of the entire population above 30 ng/ml.

https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3585561

Patterns of COVID-19 Mortality and Vitamin D: An Indonesian Study

Vitamin D Insufficient Patients 12.55 times more likely to die

Vitamin D Deficient Patients 19.12 times more likely to die

It is interesting that chemical ‘Vitamin’ D actually changes our body at a cellular level.
The cells in people who are Vitamin D normal have upgrade changes at a cellular level which are made to enable our body to stop internal inflammation and hence all common cancers, to increase the core body system strengthening the spine and warming the core (this explains why people lose 20 to 40 lbs when they correct their Vitamin D deficient and why some people are clumsy)…

… Vitamin D also actives a system that protects the brain… which explains why Vitamin D deficient people suffer long term brain damage. Their IQ is actually lower. Very sad and hidden from those most affected.

For Vitamin D status, cases were classified based on their serum 25(OH)D levels:

(1) normal – serum 25(OH)D of > 30 ng/ml,

(2) insufficient – serum 25(OH)D of 21-29 ng/ml, and

(3) deficient – serum 25(OH)D of < 20 ng/ml.

Ron
Reply to  John VC
July 9, 2020 6:17 am

…and intend to keep it that way with a strong and healthy immune system –not vaccinations.

Ehm, vaccinations are way more likely to boost the immune system than the opposite so that doesn’t make any sense at all. That is actually where possible side effects are originating from and why there is the hypothesis about TBC vaccination and protection from SARS-CoV-2 in the first place.

icisil
Reply to  Old.George
July 7, 2020 9:49 am

EGCG is another, and is probably better absorbed than quercetin.

Zinc ionophore activity of quercetin and epigallocatechin-gallate: from Hepa 1-6 cells to a liposome model
https://www.ncbi.nlm.nih.gov/pubmed/25050823

Ron
Reply to  icisil
July 9, 2020 6:44 am

The liposome assay would actually be the gold standard to prove any ionophore property of HCQ.

As one can see from the 3D structure for quercetin and epigallocatechin-gallate both fulfil the criterium of negatively chargeable prosthetic groups in close proximity to work as an ionophore for divalent cations:

https://chem.nlm.nih.gov/chemidplus/structure3D/viewer/117-39-5

https://chem.nlm.nih.gov/chemidplus/structure3D/viewer/989-51-5

It would be very informative to test these in cell culture against SARS-CoV-2 replication for the Zn hypothesis. Or clioquinol as this is not known to have antioxidant properties that could confound any finding but is a well established Zn ionophore.

mario lento
Reply to  Ron
July 9, 2020 11:37 am

Ron: This from a MedCram shows a chart at 7:50 into the video:

Ron
Reply to  Ron
July 9, 2020 1:36 pm

@mario lento
Yeah, I know but nobody really tested it with the virus AFAIK yet.

Quercetin is somewhat “problematic” in this instance cause it has a lot of other potentially beneficial effects in the context of a viral infection…

– antioxidant
– anti-inflammatory
– autophagy-inducing
etc.

… though the data is not completely uncontroversial.

So to prove the action is through an ionophore effect it would be better to use another ionophore with as less as possible off-target effects.

mario lento
Reply to  Ron
July 9, 2020 1:44 pm

Oh, yes, I was just showing a chart which claims observation ionophore activity of several substances.

quercetin does seem to help with tamping down (I will use the term misguideded) macrophages so it helps in autoimmune (allergies) disease. What I do not know is if it suppresses all immune response or selectively reduces improper immune response.

Grumpy Bill
Reply to  Old.George
July 7, 2020 9:52 am

I was taking Quercetin + Zinc gluconate daily until I got a script for HCQ. I’ve convinced my wife to take it.

Krishna Gans
Reply to  Grumpy Bill
July 7, 2020 10:25 am

In case of Zn deficit, eat oysters ! 😀 😀
Vegans should eat wheat germ, at least 😀

bonbon
Reply to  Krishna Gans
July 7, 2020 12:09 pm

Oysters only work with Guinness. Many a festive proof of that. They get their oats in volumes!
An uncle, MD, surgeon, swore by it.

mario lento
Reply to  Krishna Gans
July 7, 2020 12:33 pm

Krishna: [this is personal] I have been taking a Saw Palmetto prostate formula which has pumkin seed, and recently I found it had 15mg of Zn per capsule of which I was taking three times per day for some 4 years. It works great for flow.

I also had been taking Ca/Mg/Zn w/D because it’s a good mixture of minerals. (I take lots of other supplements and powdered juiced veggies).

So I recently reduced the dosage of both of these products since I don’t want to be taking so much Zn…

I think that taking 30mg Zn/day is still a bit over the top still…

Anyway, after I started taking 1500mg day of supplemental Quercetin, with NAC, I noticed my lungs (exerciser induced bronchitis) and sinus sensitivity vanished.

It seems the Quercetin brought everything together for me…

Over the years, I used to get sick for weeks and then feel crappy for months. Over the past 4 years, when something bad goes around, I either miss it or get it for a couple days…

With the Quercetin, and EGCG I am sort of looking forward to the flu season to test out my immunity… Oh, and my Vit D is 62ng/mL with K (I do not supplement K) is off the charts >2,500pg/mL

Clyde Spencer
Reply to  Grumpy Bill
July 7, 2020 3:25 pm

Grumpy
One of the common arguments for the use of HCQ is to make zinc more readily available to the body. Many people are convinced that using zinc gluconate is effective in aborting viral infections that cause colds. If an ionophore is necessary for the bio-availability of zinc, why isn’t it included in the OTC zinc gluconate? Even allowing for the fact that zinc gluconate might be more effective in conjunction with an ionophore, it appears that sufficient zinc can be acquired to be effective, even in the absence of an ionophore, without becoming toxic. A lot of hand waving to rationalize something that may or may not work for COVID-19. I remain agnostic and await high quality trials.

mario lento
Reply to  Clyde Spencer
July 7, 2020 3:54 pm

“I remain agnostic and await high quality trials.”

Meanwhile 4 months have gone by and potentially, 70k fewer deaths at no risk by not waiting. It’s called being pragmatic.

Dave Fair
Reply to  mario lento
July 7, 2020 4:38 pm

+42^42, Mario.

Grumpy Bill
Reply to  Clyde Spencer
July 8, 2020 10:01 am

Clyde Spencer:
I am also somewhat agnostic. But, my thinking is that Quercetin is cheap, and the zinc gluconate is free through my health plan, and the combo is doing no harm, so why not take it…

mario lento
Reply to  Grumpy Bill
July 8, 2020 10:28 am

Just be careful with Zn… some is great too much interferes with Cu balance…

OweninGA
Reply to  Old.George
July 7, 2020 10:40 am

Where are you finding a zinc supplement? All the pharmacies and supermarkets around here have been out of stock since February.

John VC
Reply to  OweninGA
July 7, 2020 10:47 am

Been buying my supplements at a local “health food” store. Costco on line or amazon should work also.

icisil
Reply to  OweninGA
July 7, 2020 11:04 am

Online at Walmart and Amazon. Some items ship free by themselves, but most everything does with $25-35 order.

mario lento
Reply to  Old.George
July 7, 2020 12:16 pm

Yes, also EGCG, in green tea, so I add green tea extract. I am careful now not to overload on Zn because being in balance is also important. Cu competes with Zn and is also crucial to a well functioning body.

July 7, 2020 8:52 am

Yes, the article relies on surveys, and some of them go back in time. But the published information is mounting in support of HCQ+. And the efficacy is proving out both pre- and post-exposure. Diagram showing HCQ role in relation to disease stages:
comment image

Previous posts provide examples of HCQ treatment along with other proven medicines (eg. Azithromycin) and supplements (eg. Zinc. vitamins C and D). Summarized in the chart above is the role of HCQ+ according to the progression of the disease Covid19.

HCQ Prevents Covid19

The first column on the left is sometimes called PrEP, or pre-exposure to the virus SARS CV2. Now we are getting studies confirming that HCQ plays an important prophylactic role in blocking the virus from taking hold when someone is infected. The Times of India June 19, 2020, article is HCQ beneficial as preventive drug: SMS doctors told ICMR.
https://timesofindia.indiatimes.com/city/jaipur/hcq-beneficial-as-preventive-drug-sms-docs-told-icmr/articleshow/76453826.cms
My synopsis: https://rclutz.wordpress.com/2020/07/07/hcq-proven-first-responder-to-sars-cv2/

DocSiders
July 7, 2020 9:32 am

Conclusion: 11% of American Doctor respondents had severe TDS.

So, having a personal physician that suffers from TDS should be considered a predisposing condition (a co-morbidity of sorts)…increasing the likelihood of death by Covid-19.

J Mac
Reply to  DocSiders
July 7, 2020 11:26 am

Trump was right…. which only makes the TDS afflicted even more irrational and irate.

commieBob
July 7, 2020 9:38 am

Am I right in thinking that the majority of the anti-hydroxychloroquine propaganda originates in the United States?

Dave Fair
Reply to  Henry Pool
July 7, 2020 1:56 pm

Please note that the WHO (ChiCom) study was for severely ill WuFlu patients only. Propaganda is always carefully worded. Such leftist/Marxists propaganda is particularly effective on the susceptible like St. Nicholas.

HCQ+ is recommended for prophylaxis and early symptoms’ treatment only. Once one hits the hospital, outcomes are primarily random and depend on one’s personal characteristics.

Thank the Donald for getting us out of the WHO. Also, F**k the UN and all its subsidiaries such as the IPCC, UNESCO, etc.

Dave Fair
Reply to  Henry Pool
July 7, 2020 4:09 pm

Henry, your severe TDS is on display; you failed to reference a follow-on study that debunked your citation. All you had to do in scroll down your article to find the follow-on study. Propaganda is ugly. You are ugly; screw off, twit.

mario lento
Reply to  Dave Fair
July 7, 2020 4:44 pm

Well done. Henry, like the LEFT, will erase history to change outcomes. They seek a predetermined outcome, not truth. So sad.

Dave Fair
Reply to  mario lento
July 7, 2020 5:06 pm

Political ideology is ugly, Mario. The Democrat Left is willing to kill thousands to put a demented old man in as President of the US. At times, I am tempted to believe that the long-term health of America’s democratic free market experiment needs a good dose of short-term Marxism/Socialism government insanity to remind liberals of how we got to be the most successful democracy on the planet. Without a supermajority Senate, they might not do much long-term damage.

mario lento
Reply to  Dave Fair
July 7, 2020 5:34 pm

I hate to admit, I fantasize about that.

But guess what. Trump is allowing, and I say that thoughtfully, allowing the Democrats to reveal themselves. He could clean up the cities stat. But then the media would pull a Simon or a Henry, and say Trump is a fascist against mostly civil protest. So let them suffer their consequences. You don’t hear anymore calls for Gov Cuomo as president after his (let’s call it neglectful homicide) murdered old people. He initially tried to blame everything on Trump, who over delivered.

So, Trump is handing over the Marxist to those who vote for it.
We can see where all the carnage is.

Trump is so brilliantly owning the libs, that they take the bait.

America is Watching…

PS – My full name no spaces, at gmail is my personal email address.

Dave Fair
Reply to  mario lento
July 7, 2020 5:50 pm

OK, Mario. I’ll be in touch. Watch your back.

mario lento
Reply to  Dave Fair
July 7, 2020 5:58 pm

Yes sir! Meanwhile Nick the Mck is making up stuff about me, out of whole cloth, which is evidence he has nothing. He’s been exposed…

Henry Pool
Reply to  Henry Pool
July 7, 2020 5:02 pm

Mr. Fair, the drug does not prevent COVID-19. The drug does not cure COVID-19. There are now well over half a million deaths attributed to the virus. The drug has failed to help anywhere in the world so take your “TDS” and shove it you know where.

Dave Fair
Reply to  Henry Pool
July 7, 2020 5:28 pm

Henry, since I never said HCQ+ prevents or cures the ChiCom virus nor its resultant WuFlu, I surmise your reading skills are on par with your reasoning skills. Since there are worldwide studies showing the drug combination has helped numerous people possibly avoid an ugly death, you are either ignorant of that fact or a liar.

Again, since my diagnosis of WuFlu, I have no sense of humor left in dealing with obvious Trolls like you. I will take HCQ+. If you catch the ChiCom virus and develop the WuFlu, get back to us on WUWT if you change your mind about taking HCQ+. Until then, I heartedly suggest you F**k off; you have no idea as to what you are talking about and could mislead the gullible.

Dave Fair
Reply to  Henry Pool
July 7, 2020 5:33 pm

P.S., Henry: My anger with you and your ilk is showing up in my comments on WUWT. It results in them being thrown in temporary moderation, slowing my responses. Anyway, you are still a twit, no matter the trouble I get into with the Moderators.

Henry Pool
Reply to  Henry Pool
July 7, 2020 6:24 pm

Mr. Fair, this virus is not political. This virus doesn’t care about socialism nor does it care about capitalism. This virus is a global phenomena. India is the largest manufacturer of HCQ, and it’s case load is growing very fast. There is no “TDS” in India, so tell me, how come the physicians in India haven’t stopped this virus with all the HCQ they make?

Dave Fair
Reply to  Henry Pool
July 7, 2020 6:42 pm

Either you don’t read or you can’t comprehend simple facts, Henry. Goodby.

Derg
Reply to  Henry Pool
July 7, 2020 6:36 pm

Henry if you contracted Covid and your doctor prescribed HCQ + zinc would you take it?

If he/she didn’t prescribe would you take HCQ + zinc ?

If not what would you do?

Henry Pool
Reply to  Henry Pool
July 7, 2020 6:51 pm

Mr. David Fair…
.
.
Calling the virus “ChiCom virus” and the resulting affliction “WuFlu” betrays your lack of scientific/medical acumen. The proper name of the pathogen is SARS-CoV-2 and the resulting disease is called COVID-19.
..
When and if you start using the proper scientific and medical nomenclature, we can continue this discussion.

William Astley
Reply to  Henry Pool
July 7, 2020 2:33 pm

WHO Stop investigating HCQ.

Why does the WHO Stop investigating HCQ? Why is there fake HCQ research? Fake ‘research’ is sciency stuff written and published, to push an agenda.

Why was there a FAKE Lancet HCQ study that alleged that HCQ caused 25% of the covid patients to die of heart attacks and showed no benefit.

‘IT’ is the
The global phenomena ….. …..to hide the fact that early covid treatment, with low dosage HCQ/AZ plus zinc with reduces the covid death rate by more than a factor of 10 and reduces hospitalization by 84% with zero heart attacks.

We all know, that everything that the WHO, does is approved by China. No surprise.

It is a fact that China is the most powerful country (there are no checks and balances in China, people disappear, there is no defence) in the world and you are just a single person, from a small country, and you like the gravy train, what would you do?

From China’s standpoint, if the US takes years to find out that HCQ/AZ plus zinc reduces the death rate for covid by more than a factor of 10 and reduces hospitalization by 84%, if the treatment is started early,…

Then China wins and the US loses. All of the US loses. There is no left or right side, to US citizens dying and suffering needlessly.

bonbon
Reply to  William Astley
July 7, 2020 5:53 pm

The Lancet, editor Horton, is British. And they want Hong Kong back with Sen. Cruz doing his antifa cameo.
It takes years for Americans to notice that.

Gums
Reply to  commieBob
July 7, 2020 10:16 am

Salute!

Direct hit, COMMIE!
It appears, without peer-reviewed truth studies, that certain political tribes and many folks down in the swamp fear for their jobs and influence upon society, I opine.
All must realize that anything that comes outta the mouth or tweet of “orange man bad” must be countered or attacked.

No mystery why U.S. media and info has little info about other country failures and successes with malaria compounds that might actually help your cells to fight this virus.

Remember, the “science is settled”, so do not try any home remedies that have not gone thru three years of “clinical” trials.

Gums sends…

Bob boder
Reply to  Gums
July 7, 2020 11:16 am

you know i like the Gums ……. part at the end its always good.

Citizen Smith
Reply to  commieBob
July 7, 2020 10:49 am

Commie B,

I always enjoy your comments.

Someone said somewhere on TV that hcl is broadly in use, well understood for treatment of other diseases, low risk, easily available, inexpensive and could work. He followed up with “what do you have to lose?” Simple logic, right?

That’s when the “new treatment” skidded off into the political ditch. The 97% scientists started blathering uninformed opinions. Governors started outlawing treatments. Federal agencies issued newly discovered warnings. Then it spread to other countries like an out of controlled virus. People started dying from TDS complications. Strange times.

Dave
July 7, 2020 10:06 am

How many people did CNN kill with their scare mongering?

noaaprogrammer
Reply to  Dave
July 7, 2020 11:26 am

Somewhere I heard (so a statistical study is needed) that there has been a slight increase in deaths due to heart attacks because some people are afraid to get medical help when they first feel such symptoms because they have more fear of the corona virus. (Obviously such a fear would have to be inferred or obtained from a person who actually heard it from the now-deceased heart attack victim.)

July 7, 2020 10:46 am

A curious “paper”. No author stated up front; I presume it is Leo Goldstein. Publication status? Well, there is a note:
“Except for this paragraph, this paper appears here exactly as it was submitted to medrxiv.org on June 30 (MEDRXIV/2020/143800). It was rejected today, on July 4: “We regret to inform you that your manuscript will not be posted. A small number of papers are deemed during screening to be more appropriate for dissemination after peer review at a journal rather than as preprints.“”

Medrxiv is an unrefereed preprint server, so it is indeed one of a small number to have been rejected.

And so who exactly is recommending HCQ? Four surveys are quoted, but only one (Sermo W3, April 15) gives doctors rating its effectiveness. The survey claims 4016 respondents, but, it turns out, only 1337 have treated Covid, and of those only half used HCQ. And many speak well of it. But that is barely enough time for the results to have come in, since the article claims “It became instantly popular among physicians on March 20-21”.

Bob boder
Reply to  Nick Stokes
July 7, 2020 11:18 am

Nick, sorry yo came in second to Mcginley— try again next time!

TRM
Reply to  Nick Stokes
July 7, 2020 11:56 am

https://c19study.com/

The studies that have negative results have “late stage trial” or some similar phrase. Starting treatment late is known to fail so why are they doing it?

53 studies (32 peer reviewed).

Grumpy Bill
Reply to  Nick Stokes
July 7, 2020 12:31 pm

The author’s name is directly under the heading.

hornblower
Reply to  Nick Stokes
July 7, 2020 8:08 pm

I read this site because I believe climate change is exaggerated. I have no idea how it has become a forum for political discussion regarding the present administration and possibly the next one. Wear a damn mask and stick to the science.

Nicholas McGinley
Reply to  hornblower
July 9, 2020 9:30 am

+++++

TRM
July 7, 2020 11:01 am

Of course we could all line up to be guinea pigs in the fast tracked Moderna vaccine trial like this unfortunate sot did:

https://childrenshealthdefense.org/news/modernas-guinea-pig-sickest-in-his-life-after-being-injected-with-experimental-vaccine/

And why does the person who wants to vaccinate everyone with a vaccine he will make a killing off NOT VACCINATE HIS OWN KIDS?

https://www.uspoliticsandnews.com/why-didnt-bill-gates-vaccinate-his-own-children/

My SWAG is that they are fast tracking it and throwing caution to the wind because it will become a solution looking for a problem shortly.

Fran
July 7, 2020 11:22 am

The opinions of doctors regarding what treatment works is largely controlled by confirmation bias. The DES (diethylstilbestrol) story tells it all. DES is a synthetic progestin with prominent androgenic effects given to women who threatened to abort. Doctors swore by it for 17 years after it was proven in double blind trials to be ineffective. Then a cluster of rare nasty vaginal/cervical cancers started showing up in young women. Turned out to be due to in utero exposure to DES. Further investigation found that the women had histories of male level of activity in childhood and there was a large increase in the frequency of homosexuality. It is one of the classic pieces of evidence that hormones during early development alter brain development.

The point here is that a physician who has done something and sees a positive result attributes the result to his/her action. When the result is negative, it is attributed to the treatment being too late or the pathology to great. In the case of the WuFlu, it is apparent that virtually all people without gross comorbidities will recover. Thus most doctor’s experience is with survival. Therefore, whatever they did was effective against something the media kept saying was terribly lethal.

Doctor’s opinions are NOT evidence for much of anything. My big bitch is the quacks (consultants) who want to put my husband on drugs that reduce ‘cardiovascular events’ but do not decrease all cause mortality. All without considering what effects side effects have on quality of life. As with COVID 19, this is done by trying to scare the patient into submission.

William Astley
July 7, 2020 11:26 am

The Swamp is fighting as hard as possible to hide this super good HCQ/AZ plus zinc early treatment data.

Why the heck is it taking the USA so long to start using HCQ/AZ plus zinc as the standard early treatment for Covid? Evidence based, scientifically sound decisions.

How many people have to die, of Covid, for Politics? Is there anyone on the Left that has the courage to speak for the people, rather than the PARTY?

When is the fake news and PBS going to report this astonishing paradigm changing data HCQ/AZ earlier covid treatment outcome?

HCQ/AZ plus, Zinc early treatment resulted in a 84% reduction in hospitalization as compared to the current standard covid treatment….

…. And a reduction in covid deaths, of more than a factor of 10, as compared to the standard treatment. MORE THAN A FACTOR OF TEN.

The earlier, treatment is started, the better.

This study and others shows, HCQ/AZ plus zinc drastically reduce viruses count.

If the virus does not replicate it cannot do damage. Giving HCQ/AZ plus zinc, to people after the virus has replicated does not help.

https://www.preprints.org/manuscript/202007.0025/v1

COVID-19 Outpatients – Early Risk-Stratified Treatment with Zinc Plus Low Dose Hydroxychloroquine and Azithromycin: A Retrospective Case Series Study

Therefore, the odds of hospitalization of treated patients were 84% less than in the untreated group.

One patient (0.7%) died in the treatment group versus 13 patients (3.5%) in the untreated group (odds ratio 0.2, 95% CI 0.03-1.5; p=0.16).

There were no cardiac side effects.

DonM
Reply to  William Astley
July 7, 2020 2:09 pm

Some of them still have not accepted that Trump won.

Some would watch their grandmother die rather than concede that Trump is right.

mario lento
Reply to  DonM
July 7, 2020 2:36 pm

Nah, Leftist will make sure that only OTHER people’s grandma would die. Take that to the bank… sarc/…

If in 2019, someone said, and I am winging it here:

“THE USA would lock down the country, prevent businesses from opening, arrest people who go out in the sunshine at parks or who go to church –while forcing infected people to go to be confined within most at risk populations against there will, all while instigating and endorsing riots and mass destruction, removing historic statues, painting Marxists slogans in front of City Hall, Trying to pass mail-in-only voting, while at the same time devising fake medical studies to scare people away from treatments of a disease”

One would be right to respond: “Tinfoil Hat Conspiracy Theory”

Yet, here we are.

J Mac
July 7, 2020 11:46 am

Leo Goldstein,
Thanks! An informative retrospective.

bluecat57
July 7, 2020 12:13 pm

Can’t believe WUWT either. Do your own research.

Dave Fair
Reply to  bluecat57
July 7, 2020 2:02 pm

+42^42, Bluecat, regarding any topic. One finds nonsense on WUWT, like anyplace else.

icisil
July 7, 2020 1:06 pm

Breaking news: Trump has notified Congress that the US has withdrawn from the WHO.

mario lento
Reply to  icisil
July 7, 2020 1:14 pm

Great and this!!! https://www.theepochtimes.com/trump-urges-fda-to-act-now-on-hydroxychloroquine-after-new-study-shows-positive-effect_3414918.html

Trump is doing the right thing, especially because Nicholas McGinley disagrees!

Simon
Reply to  mario lento
July 7, 2020 1:47 pm

Brilliant. The man who think we can inject disinfectant knows best. During a pandemic he fires the group who are working to overcome this problem. I wonder why? Maybe he wants to distract from his olympic level poor decisions. And I see Trumps “best fwend” Jair Bolsonaro has tested positive for the coronavirus. What an irony that the man who called it a hoax now has it. He will be fine though he has taken Dr Trumps advice and started on hydroxychloroquine.

mario lento
Reply to  Simon
July 7, 2020 1:55 pm

So, you support the following:

* WHO lied about where it found out about coronavirus

* The health organization took China’s word for it that the virus appeared in late December, when it started earlier.

* The health organization chastised Trump for instituting a travel embargo on China early in the pandemic

* WHO took China’s word for it when it claimed that the virus did not travel from person to person

* The health organization lavished praise on China for reacting quickly to the virus when it had not

* WHO praised China for releasing the genome sequence for the virus, though it took a crucial 17 days to do so and under much pressure

* WHO is so cozy with China that it removed Taiwan from a map and included it as part of China

Good news as that your ilk are being exposed and erased, largely through the efforts and leadership of one strong man with the help of a wonderful team of patriots. America is watching, and your team is being exposed. You are a stain. I know, I could not resist the ad hominem metaphor…

Simon
Reply to  mario lento
July 7, 2020 2:43 pm

“Good news as that your ilk are being exposed and erased, largely through the efforts and leadership of one strong man”
Yes well that “strong” man has to lift his popularity somewhat (https://projects.fivethirtyeight.com/trump-approval-ratings(https://projects.fivethirtyeight.com/trump-approval-ratings/) before he can erase me.
And by the way the WHO were not the only ones praising China. I seem to recall Twumpy saying how great they were at the start of the pandemic.

mario lento
Reply to  Simon
July 7, 2020 2:55 pm

Simon, you are the perfect self eraser. You’re in a class by yourself… a perfect barometer. If you occasionally said something reasonable, you’d be less reliable a measuring device.

Dave Fair
Reply to  Simon
July 7, 2020 4:48 pm

Only until President Trump learned the facts about ChiCom and WHO duplicity, Simon. Your TDS is tedious.

Simon
Reply to  mario lento
July 7, 2020 10:16 pm

“Only until President Trump learned the facts about ChiCom and WHO duplicity…”
It’s true he did change his tune on China, but that was because he made maybe the single most damaging call in US history…. to minimise the threat of the pandemic. Now we are at 133,000 deaths (and counting). So Trump is doing what Trump does… blaming someone else. His behaviour now is so predictable, you don’t have to be Einstein to see this coming.
First rule of the Trump playbook. When things are going well, it is all his doing. When things go wrong… it is someone else’s fault.

Dave Fair
Reply to  Simon
July 7, 2020 2:06 pm

TDS BS from Simon.

Simon
Reply to  Dave Fair
July 7, 2020 2:39 pm

Yes Trump is deranged for sure.

mario lento
Reply to  Simon
July 7, 2020 2:49 pm

Simon, as I have proven before, is an inverse barometer for truth. So he is batting 1000.

Translation from Simon: “I know you are but what am I?” I was guilty of similar behavior at 6 years old, until I learned more words for which to argue my side of the story.

Derg
Reply to  Simon
July 7, 2020 5:45 pm

You are a known liar. Shame on you.

icisil
Reply to  mario lento
July 7, 2020 3:25 pm

Trump’s next move needs to be to fire Fauci. That guy is diametrically opposed to the well-being of America.

Fauci Downplays Lower Coronavirus Death Rate as ‘False Narrative’
https://www.breitbart.com/politics/2020/07/07/fauci-downplays-low-coronavirus-death-rate-as-false-narrative/